ID A0A179G9Z1_METCM Unreviewed; 932 AA.
AC A0A179G9Z1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Aimless RasGEF {ECO:0000313|EMBL:OAQ74310.1};
GN ORFNames=VFPPC_01843 {ECO:0000313|EMBL:OAQ74310.1};
OS Pochonia chlamydosporia 170.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Pochonia.
OX NCBI_TaxID=1380566 {ECO:0000313|EMBL:OAQ74310.1, ECO:0000313|Proteomes:UP000078397};
RN [1] {ECO:0000313|EMBL:OAQ74310.1, ECO:0000313|Proteomes:UP000078397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=170 {ECO:0000313|EMBL:OAQ74310.1};
RX PubMed=27416025;
RA Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yang Y., Yin W.B., Xie B.;
RT "Biosynthesis of antibiotic leucinostatins in bio-control fungus
RT Purpureocillium lilacinum and their inhibition on phytophthora revealed by
RT genome mining.";
RL PLoS Pathog. 12:E1005685-E1005685(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAQ74310.1}.
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DR EMBL; LSBJ02000001; OAQ74310.1; -; Genomic_DNA.
DR RefSeq; XP_018150393.1; XM_018281601.1.
DR AlphaFoldDB; A0A179G9Z1; -.
DR STRING; 1380566.A0A179G9Z1; -.
DR GeneID; 28845595; -.
DR KEGG; pchm:VFPPC_01843; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000078397; Chromosome 1.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000078397}.
FT DOMAIN 452..579
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 677..915
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 104109 MW; 48279685343C55DC CRC64;
MTSKSSNTSS SRKSRRTSDS PATLPKRRSS STATPTQSNT TSSTSTPTTN TGKRRPSATT
RDSTQTNASS SVFSRSSIST GITAASSSAG AGASALSPAD GTTAGGDRDS FVSIVDDPFF
QRFHPVITAH AEREASDEST SAEPQNDSDD NNNNKTQRWP PPRRESLTIG PSQYWPQPIS
TMESYNIAII GADAVGKSTF VQRVLQLSRP PVTNTSSARI QVDNVTHMIT LVELDLEHFE
LNPAQPIQWP KQINGHIVPR VDAALILYDV TDDGSIRQLP KTVAALTNSG LPAMLGACKC
DCPEDDWEIN ADELANHQYF KPCIGQYKIS IDRPDISKAC IISVIRAAVM HRRDESGETV
SRRRAQSAAN LEAPDPSAGR PLSEHSKHSR ASSDFSILKT FPNPQSNETY RFRVDKPGTD
SFLDIDESDS ESHRYSDDIP ILQRNDDVIV EKHPKIAGVT FEELVDRLLA PRLSRADNNF
SDIFLCLYRK FAAPGQLFSA ILVRLDKVRD DKTAHYLTKT ATQLRIIEVV AKWVSLYPGD
FARPTTRRNL EDFIKHLSTE PIFAIAAQQM RRNLFFNVIE DDDTGWANSD NSGDEIASKI
LSKEMSDLSA GINALQFDGE TDSLGGSENP STDKGSRLGN QFQFNSYEEY EREATVLEPS
DHLPMNKFRY HIFMDISEYD IADELTRIDW IMFSSIRIRD FVRHVSLSAS QKDKCKSLQN
VNRMISHFNH IAKWVANMIL LRDKAKHRAQ MLEKFMNIAL KLRQLNNYNG LAAVLAGING
TAIHRLAQTR ALVPTEVQKR FARLVILMGT QKSHFAYRLA WENSPLPRIP FIPLHRRDLV
SAEEGSKTFL GPNDDRINWK KFEILGEVLL PIMKSQGAAY PNLAKHETAR DLILGCRMPA
DDEEIYQRSL QLESSASGQI EPSKKKFPWF AK
//
