ID A0A179HCT4_PURLI Unreviewed; 316 AA.
AC A0A179HCT4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Eukaryotic translation initiation factor 2 alpha subunit {ECO:0000313|EMBL:OAQ87864.1};
GN ORFNames=PCL_02172 {ECO:0000313|EMBL:PWI68403.1}, PLICBS_003641
GN {ECO:0000313|EMBL:GJN69592.1}, VFPBJ_01905
GN {ECO:0000313|EMBL:OAQ87864.1}, VFPFJ_06328
GN {ECO:0000313|EMBL:OAQ89914.1};
OS Purpureocillium lilacinum (Paecilomyces lilacinus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Purpureocillium.
OX NCBI_TaxID=33203 {ECO:0000313|EMBL:OAQ87864.1, ECO:0000313|Proteomes:UP000078240};
RN [1] {ECO:0000313|EMBL:PWI68403.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=36-1 {ECO:0000313|EMBL:PWI68403.1};
RA Wang D.B., Wang M.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PWI68403.1, ECO:0000313|Proteomes:UP000245956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=36-1 {ECO:0000313|EMBL:PWI68403.1,
RC ECO:0000313|Proteomes:UP000245956};
RX PubMed=27486440; DOI=10.3389/fmicb.2016.01084;
RA Xie J., Li S., Mo C., Xiao X., Peng D., Wang G., Xiao Y.;
RT "Genome and transcriptome sequences reveal the specific parasitism of the
RT nematophagous Purpureocillium lilacinum 36-1.";
RL Front. Microbiol. 7:1084-1084(2016).
RN [3] {ECO:0000313|EMBL:OAQ87864.1, ECO:0000313|Proteomes:UP000078240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PLBJ-1 {ECO:0000313|EMBL:OAQ87864.1}, and PLFJ-1
RC {ECO:0000313|EMBL:OAQ89914.1};
RA Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yin W., Xie B.;
RT "Biosynthesis of antibiotic leucinostatins and their inhibition on
RT Phytophthora in bio-control Purpureocillium lilacinum.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:GJN69592.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 284.36 {ECO:0000313|EMBL:GJN69592.1};
RA Alimu Y., Kusuya Y., Yamamoto T., Shigemune N., Takahashi H., Yaguchi T.;
RT "Tolerabce induction of polyhexamethylene biguanide on Purpureocillium
RT lilacinum strains.";
RL Submitted (DEC-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the eIF-2-alpha family.
CC {ECO:0000256|ARBA:ARBA00007223}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAQ87864.1}.
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DR EMBL; BQKW01000002; GJN69592.1; -; Genomic_DNA.
DR EMBL; LSBH01000001; OAQ87864.1; -; Genomic_DNA.
DR EMBL; LSBI01000005; OAQ89914.1; -; Genomic_DNA.
DR EMBL; LCWV01000015; PWI68403.1; -; Genomic_DNA.
DR RefSeq; XP_018178633.1; XM_018323403.1.
DR STRING; 33203.A0A179HCT4; -.
DR GeneID; 28888452; -.
DR KEGG; plj:VFPFJ_06328; -.
DR OMA; DVNEHQR; -.
DR OrthoDB; 4371132at2759; -.
DR Proteomes; UP000078240; Unassembled WGS sequence.
DR Proteomes; UP000078340; Unassembled WGS sequence.
DR Proteomes; UP000245956; Unassembled WGS sequence.
DR Proteomes; UP001056679; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd04452; S1_IF2_alpha; 1.
DR Gene3D; 3.30.70.1130; EIF_2_alpha; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR044126; S1_IF2_alpha.
DR InterPro; IPR024055; TIF2_asu_C.
DR InterPro; IPR024054; TIF2_asu_middle_sf.
DR InterPro; IPR011488; TIF_2_asu.
DR PANTHER; PTHR10602; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR PANTHER; PTHR10602:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR Pfam; PF07541; EIF_2_alpha; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF110993; eIF-2-alpha, C-terminal domain; 1.
DR SUPFAM; SSF116742; eIF2alpha middle domain-like; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:OAQ87864.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000078340}.
FT DOMAIN 17..88
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 279..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..301
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 316 AA; 35725 MW; A82EBA488702B71E CRC64;
MSLTNCRFYE EKYPEIDSFV MVNVKQIAEM GAYVKLLEYD NIDGMILLSE LSRRRIRSIQ
KLIRVGRNEV VVVLRVDKEK GYIDLSKRRV SPEDMVKCEE RYNKSKTVHL IMRHVAEKTQ
TPIETLYETI AWPLNRKYGH AIDAFKLSIT NPEVWNDITF PSQPVSDELK LYISKRLTPQ
KTKVRADIEV TCFGYEGIDA VKTALRTAEA GNSTAEAESS GTEVKVKLVS PPLYVLTSSC
LDKNLGITRL QEAITDIKKS IEGAGGHLVV KMEPKAVTES DDAELQALME KRERENAEVS
GDESMSESDD NIPETV
//
