ID A0A179HKX7_PURLI Unreviewed; 342 AA.
AC A0A179HKX7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 4 {ECO:0000256|ARBA:ARBA00020629, ECO:0000256|RuleBase:RU364141};
DE AltName: Full=Mediator complex subunit 4 {ECO:0000256|ARBA:ARBA00031257, ECO:0000256|RuleBase:RU364141};
GN Name=MED4 {ECO:0000256|RuleBase:RU364141};
GN ORFNames=PCL_04720 {ECO:0000313|EMBL:PWI66876.1}, PLICBS_003826
GN {ECO:0000313|EMBL:GJN69774.1}, VFPFJ_06533
GN {ECO:0000313|EMBL:OAQ90120.1};
OS Purpureocillium lilacinum (Paecilomyces lilacinus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Purpureocillium.
OX NCBI_TaxID=33203 {ECO:0000313|EMBL:OAQ90120.1, ECO:0000313|Proteomes:UP000078340};
RN [1] {ECO:0000313|EMBL:PWI66876.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=36-1 {ECO:0000313|EMBL:PWI66876.1};
RA Wang D.B., Wang M.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PWI66876.1, ECO:0000313|Proteomes:UP000245956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=36-1 {ECO:0000313|EMBL:PWI66876.1,
RC ECO:0000313|Proteomes:UP000245956};
RX PubMed=27486440; DOI=10.3389/fmicb.2016.01084;
RA Xie J., Li S., Mo C., Xiao X., Peng D., Wang G., Xiao Y.;
RT "Genome and transcriptome sequences reveal the specific parasitism of the
RT nematophagous Purpureocillium lilacinum 36-1.";
RL Front. Microbiol. 7:1084-1084(2016).
RN [3] {ECO:0000313|EMBL:OAQ90120.1, ECO:0000313|Proteomes:UP000078340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PLFJ-1 {ECO:0000313|EMBL:OAQ90120.1};
RA Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yin W., Xie B.;
RT "Biosynthesis of antibiotic leucinostatins and their inhibition on
RT Phytophthora in bio-control Purpureocillium lilacinum.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:GJN69774.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CBS 284.36 {ECO:0000313|EMBL:GJN69774.1};
RA Alimu Y., Kusuya Y., Yamamoto T., Shigemune N., Takahashi H., Yaguchi T.;
RT "Tolerabce induction of polyhexamethylene biguanide on Purpureocillium
RT lilacinum strains.";
RL Submitted (DEC-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364141}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC {ECO:0000256|ARBA:ARBA00009626, ECO:0000256|RuleBase:RU364141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAQ90120.1}.
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DR EMBL; BQKW01000002; GJN69774.1; -; Genomic_DNA.
DR EMBL; LSBI01000005; OAQ90120.1; -; Genomic_DNA.
DR EMBL; LCWV01000022; PWI66876.1; -; Genomic_DNA.
DR RefSeq; XP_018178839.1; XM_018323608.1.
DR STRING; 33203.A0A179HKX7; -.
DR GeneID; 28888657; -.
DR KEGG; plj:VFPFJ_06533; -.
DR OMA; WPLEDKI; -.
DR OrthoDB; 2728817at2759; -.
DR Proteomes; UP000078340; Unassembled WGS sequence.
DR Proteomes; UP000245956; Unassembled WGS sequence.
DR Proteomes; UP001056679; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019258; Mediator_Med4.
DR PANTHER; PTHR13208; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR PANTHER; PTHR13208:SF2; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4; 1.
DR Pfam; PF10018; Med4; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364141};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364141};
KW Reference proteome {ECO:0000313|Proteomes:UP000078340};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364141};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364141}.
FT REGION 135..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 342 AA; 38534 MW; B89E2BAA1F41B000 CRC64;
MDKYIDSRFE RLEKALSSLI DSVAKYHPSV SQAEELKAAD TELGKGLEQV QEHQRNHLRI
QQLRQTSAAL DTQIKDTLTS LAEARRGIVT TRTTTFPREP NYPIAYDKLL SYARRISKTT
LPPAATINAA TAAGTVPASP EGQTPAAADS QPQSAVTPSA RTPSRTQSPA PNGIPSQAPL
SEPPTQQTAL SMNTSLPEGM SQYLNPLSGQ LFFPWPLEDK IRSGALASYQ MLVEQGIDPK
GYDPVTEEER KRKEEEERKA KEEQEQKERE EREEQIREER ERLRVERERQ REREQEEWRR
ASIAGNPPEA PGLPRTNTGA GERRQFQFTN LDDLDDDDDD DE
//
