ID A0A179HVZ4_PURLI Unreviewed; 1506 AA.
AC A0A179HVZ4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=VFPFJ_02722 {ECO:0000313|EMBL:OAQ93560.1};
OS Purpureocillium lilacinum (Paecilomyces lilacinus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Purpureocillium.
OX NCBI_TaxID=33203 {ECO:0000313|EMBL:OAQ93560.1, ECO:0000313|Proteomes:UP000078340};
RN [1] {ECO:0000313|EMBL:OAQ93560.1, ECO:0000313|Proteomes:UP000078340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PLFJ-1 {ECO:0000313|EMBL:OAQ93560.1};
RA Wang G., Liu Z., Lin R., Li E., Mao Z., Ling J., Yin W., Xie B.;
RT "Biosynthesis of antibiotic leucinostatins and their inhibition on
RT Phytophthora in bio-control Purpureocillium lilacinum.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAQ93560.1}.
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DR EMBL; LSBI01000002; OAQ93560.1; -; Genomic_DNA.
DR RefSeq; XP_018182279.1; XM_018319805.1.
DR STRING; 33203.A0A179HVZ4; -.
DR GeneID; 28884854; -.
DR KEGG; plj:VFPFJ_02722; -.
DR OMA; DRCTLFG; -.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000078340; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000078340};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 8..373
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1008..1180
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1189..1495
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 106..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..648
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1347..1381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1506 AA; 163229 MW; 9E9A1ADA00EC2FA4 CRC64;
MDTAEYDTNT LLISNIASVC YRIYEPSTES SQRFASSALD VESQLRKDGH VVFYDASRRG
IWHFRLAGKE GHDNVASETL DRTLETCGHR LLLGAEGTLE PANLQKARPH PQMSQTPTTA
VSGASALDPS QRSTISGNTS QLSGAGSQEH ESQFNEVTGG DSKAIPPKTV YENFITALLL
SISSTFCSRS GATPLNYRTV LLPAVGPGSE EPSELGPENC PVLATLRAYL TTTGALVTSF
VFSRCRGLTS LSDTVTASLS LPATPIIAAP FGALTKNQFA SGTDPGSASL AQTPNTQALS
LRGGYDAHDS MWKQACLKIL KLRGVAPASL SDCTWVNLLV PKPRLLDAKI DPRRQQPLGS
TVTLPWPGPL CFRKRVVEVS ATSRVGDNLL SGHEESHDPL GDARGWFNSA PEREEKLSKR
KIERAAVARD PSLADARAPR PSVPSPATIR RPSATAASAI YPTPPDGVQH LNGVTPSFDG
TLSSPGNPMS SVPVPDVDPV SSTANNTGEV FDTSSDFHDS KRQRSDVNLL NDAEHMFGDM
GGDMFGDNDI TDADFNFFDE APDEEDIEIS MDDINDNAVT DGGIQKADEA TPNTTDVKAE
PAQDRDDAVF AKPELKHARS TQNDNAPQRG RDARTGSMKR ESSPFDPHTV FKRVRASLTE
AGQAMNTSSV ADVNRTTRTF ESMSFDPTLP MINKKYEQGG QFDYKKIAST EKPRLEPGLL
PETDYLKRHG RHMKRFRERD LQPGVLAKTS TGLDPPTARL SPARMENSLS EDDDSSAGSD
EDGSSYTTEE PTSPVKSSVK VAAPDDDVAS QVTSARDLDT FEEPDHQLAT ELPRLSKPDA
VELPLCQLFS DPEPIPLELS LGDEDFIQVA QILTDQAAIG KLDICSTDDP DSPGGSGSLS
SQLRPCEARN ALQTLRESVP SLLKNAGPVS LKGFLDIPDV PFVGQSSRVQ PRPVPGRDAS
SEQVRPSNLY QIPGPHLEVR RSDVKLSVLP SAVTFWESLG LAPSSGRKNL NAVCVFPGWP
GMKENVKTFL GRLKSVYEVL KLGSLHSMPL SADLDDGLLP YEVDRISTSP DATMTRHGSS
LVESMETLRG AMNNLTVTET NIVVYYVYSP NNPGTIVEAC SAFQRYFESY WKSLASQKLV
APNELVLQLV SADLLSAPSS LVVTPGPELV RLCMETYDRC TLFGGPMPAP AIRLEQQLPR
IIDFKLTVSP SASLIRENSA IHVAYAQSVD ERWVTAAWTD DRGNQQETAS YCLGRKGRPQ
SRSMNEVAHE IWESTLDLIS AWKVHWRIII TKCGPMDQQE IDFWVDLART EIKASVAVIL
LAVDTSPSLQ LVPPEVKLQP PSVPFHTTPV STPQANIVSP EQSGTPATPA RDSNATAATP
GTDGAGDSEA DAVLVDVTDQ TWGALVGHRL NNSSTVLDLH PALVSGYLIK RTGTRIEDAP
VLMEVNMVHT DASPRAYEPL LREMLSHFRG LGTLARARGV VRREADVRPW HIAAAEKAVR
AMYLLM
//
