ID   A0A179U6B1_BLAGS        Unreviewed;       973 AA.
AC   A0A179U6B1;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=DNA mismatch repair protein MSH5 {ECO:0000313|EMBL:OAT03544.1};
GN   ORFNames=BDBG_00250 {ECO:0000313|EMBL:OAT03544.1};
OS   Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT03544.1, ECO:0000313|Proteomes:UP000002038};
RN   [1] {ECO:0000313|Proteomes:UP000002038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC       {ECO:0000256|ARBA:ARBA00006271}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG657448; OAT03544.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A179U6B1; -.
DR   STRING; 559298.A0A179U6B1; -.
DR   VEuPathDB; FungiDB:BDBG_00250; -.
DR   OrthoDB; 9867at2759; -.
DR   Proteomes; UP000002038; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0007127; P:meiosis I; IEA:UniProt.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd03281; ABC_MSH5_euk; 1.
DR   Gene3D; 1.10.1420.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR   InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR   InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR   InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR   InterPro; IPR045076; MutS_family.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR   PANTHER; PTHR11361:SF20; MUTS PROTEIN HOMOLOG 5; 1.
DR   Pfam; PF05192; MutS_III; 1.
DR   Pfam; PF00488; MutS_V; 1.
DR   PIRSF; PIRSF005813; MSH2; 3.
DR   SMART; SM00534; MUTSac; 1.
DR   SMART; SM00533; MUTSd; 1.
DR   SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002038}.
FT   DOMAIN          780..796
FT                   /note="DNA mismatch repair proteins mutS family"
FT                   /evidence="ECO:0000259|PROSITE:PS00486"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   973 AA;  107421 MW;  DB66669D752D867A CRC64;
     MAPSSSKRET RGFNSSRSSH QRSQPRRNQR PFNSSSSGRR DRIASSARES SAAAYTENSG
     NNQVSDVVSQ LQGNIGQQDR DDENADLCQV VMAMDMKERC SVGCCYYVAA EQKLYLLEDI
     TSGGLEAIET LKLDVQPTLV LLSTRADQST PNLGQTGLGM HTADNGDQFQ LPYHLDVRPV
     QEFNFEGAKL KLASLPLSTS RSETRFLVPG DTFSLKQNGD ENDLGFTDHQ GRLLNLSGSI
     DMDNRISIGC VGAIITYLQR KRAAECLTRD SSGSELFNIK SLEMRSLRDT MFVNTDTLTS
     LQVIQSESHP NAFNQGPGKT SPGAKESLSI YGLFHHFART PHGKTRLRQR FLRPSTDAAH
     IKEGHDFIST YLRPDNGECI EKLTKSLKGI KNLRPVMVHV QKGISSGNAK FKAFKSGVWA
     TLLEFAFHAI DVHDTIRTVM GAENLDIHLR ALEKLDVAIL HQVGRIIHET VDLQSSIDEH
     RTVVKPRVDR ELDDLKETYN GLDSLLNQVA INIAGTIPSR LSNDVNVIYF PQLGFNIAMP
     LDERGRAVYD GGEQPWDQVF TTENRVYFKD FRMREMDEKF GDIYGLICEK EIEIVYEMAQ
     NVLQHEKFLV DASDICGDID SLLALVQGAS LYKLVRPQIT QDNSIVIKGG RHLLYEVTVP
     TFIPNDTLIV GGNGREGSPP NTSTQSLETS VEVAETQGPS MLLLTGPNYS GKSVYLKQVA
     LIVYMSHIGS FVPAERAKIG ITDKILTRIT TRETVSKTQS SFMIDLQQIS FALNLATEHS
     LVIIDEFGKG TESTDGAGLA CGLFEYLLSL GEKRPKVLAA THFHEIFENG FLPPRKELDF
     GYMEVQVDPA AREVENQVTY LYNFRSGRSN ASFGTNCAAL NGIDQAIISR ANEIGTLAAR
     GEDLVVICAK MSADEMGELE EAESMARRFL GADFSHGPNG AGDGCEDNSE RPEALLENII
     GKSYGSTIMT GLT
//