ID A0A179UBM5_BLAGS Unreviewed; 1543 AA.
AC A0A179UBM5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Vacuolar import and degradation protein 21 {ECO:0000256|ARBA:ARBA00029670};
GN ORFNames=BDBG_01822 {ECO:0000313|EMBL:OAT05425.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT05425.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. {ECO:0000256|ARBA:ARBA00025178}.
CC -!- SIMILARITY: Belongs to the EAF1 family.
CC {ECO:0000256|ARBA:ARBA00008913}.
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DR EMBL; GG657450; OAT05425.1; -; Genomic_DNA.
DR RefSeq; XP_002627151.1; XM_002627105.1.
DR STRING; 559298.A0A179UBM5; -.
DR GeneID; 8506962; -.
DR KEGG; bgh:BDBG_01822; -.
DR VEuPathDB; FungiDB:BDBG_01822; -.
DR OrthoDB; 1334563at2759; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:UniProt.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR46459:SF1; E1A-BINDING PROTEIN P400; 1.
DR PANTHER; PTHR46459; E1A-BINDING PROTEIN P400-RELATED; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF13921; Myb_DNA-bind_6; 1.
DR SMART; SM00573; HSA; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51204; HSA; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000002038}.
FT DOMAIN 647..722
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 915..975
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 69..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1013..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1138..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1480..1543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1013..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1480..1495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1543 AA; 169260 MW; 1F77F195D2A36A05 CRC64;
MLRDELLQSK HDEIARCVSS RKRKLSELYF ATVGFPGATD GSPQHLQYQQ REQEFLDAND
ITKGRLFNEG TLPRRPDVAP LQVSPRDDKL NQGSLSASAA DRITDSHRRK PIFSPVRIAV
SSPKLPSTGT YTETGSQDIF RPQDHTPTGT TESVAVQASS GELDIPQITP SASHDAIREK
EVSSPASTQQ TIAATVTPVT DVDMDEAPDG QDNTGTTEVP APESDLPIGS RKTVAEIQDN
ATGASLPTSD APERQHGKRS GNDLPCLATD ASPKSTDQPL SPASSRGQLS STTSVSDRTP
ATSPAKEQPQ REPQNESTTP PNSGRSIPVP MVTADISTIR RAPATPDEQL KFEAEQSSIQ
QAASKPTKNA PYTGSAFSSF QLTPENSFSS PKKPPDSHNE PDLSKSSKTS VAPENRPLVN
GALRLDTEGV KPEPVSKSHE PQSAPVTLEL PEGAGGSPLP SATRKTSTSS APTQPHFQPE
RMTTRVSSGA IRHRSVSEIL GETPKSAMDK TFDKAVSESP TATSENSQVR SRPKNKRENQ
KERSKLSTVV FPKQQSAAEK NESADLVRTP SGHTRSLNEE KDYLFTLFQA KAHYPPRSMH
LSSLLSTAHK TLTTANHFVE YQEQMDCRSL KRIYQLQHAN RWPLRQLQRS AEPERSGTHW
DVLLDHMKWM RTDFREERKW KIAAAKRCAD WCAEYVSSSD GRRAELRIPA RVPPATSKIE
ESGNHKTTPS YSDDRVDDSL PHSQPTPDLI SSMEDDSVSE GFNDEVHPDL SDGVVPAAIF
SLGSDEFTFG MERTPAFEKI LEELPLYIPI NISSETNLPQ FKRPPDSSWR KELLAVSKYA
TGKLEFTSKQ PPRKRSRYDY SDNDDDVDVD AIEIPPEQTN VALFQPQNKH IRDRIHPGQV
FRPPTEFLMP SLGFYESRQP SQWTCAEEDE LKRIVKEYSF NWSLISACLT PPSLYTSGAD
RRTPWECFEK WVQLEGLPTE MLKTPYFRAY TSRVESAQRA VLAAQQQQQQ QAQAQVQAQA
QANPQRQGSN PPPTPTAILR RRPTTPMRVE RKRSVRHLTL LDCMRKLSKK RETLLQKQQH
ATHLAASRKL NEVNQPRPPI STPAEFSRLK HERELKIQEN QEQYKQAMIA QRMAMAHRVA
QQQQAQHQQQ QQQLQQQQQH RQMPNQQALL NGIPPRNTAS APPNGVMQGI PAPSGLPNGL
PVSAALAQSR PHPGMQLPTG AQVNGMPNPG MGLKMIPQPG IPQAMNGRPG IQTQASSDNA
RIIREASRVQ EEQQRMVQSR QQQLQNQQQS FIPQGPHSSP NMSMGNMNVN PNNPAMLTFQ
AVSGVNSPSF HASSLAQGVS TASPRLNHAN VLANAAAGLP TLVSIQNTIR RTNPNMSQEQ
ITKLATERLQ HIQQQRMSQA AMNAAAGNTM GSMQTSYQMH HDGNMHQLSH ANVPNGGVPA
SMQTLQQTQG YSPLMRVTQT VQQPNRMGVN GSPAMNAAMA VQQGRSATAQ AHRSTGGQGG
HGPGPVPGPG PSPGGVSGSG QGSGVGPGPG KSPRPPQAQM ASS
//
