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Database: UniProt
Entry: A0A179UD05_BLAGS
LinkDB: A0A179UD05_BLAGS
Original site: A0A179UD05_BLAGS 
ID   A0A179UD05_BLAGS        Unreviewed;       598 AA.
AC   A0A179UD05;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   08-MAY-2019, entry version 12.
DE   SubName: Full=Tripeptidyl peptidase SED3 {ECO:0000313|EMBL:OAT05613.1};
DE   SubName: Full=Tripeptidyl peptidase SED3, variant {ECO:0000313|EMBL:OAT05614.1};
GN   ORFNames=BDBG_01978 {ECO:0000313|EMBL:OAT05613.1};
OS   Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT05613.1, ECO:0000313|Proteomes:UP000002038};
RN   [1] {ECO:0000313|EMBL:OAT05613.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SLH14081 {ECO:0000313|EMBL:OAT05613.1};
RG   The Broad Institute Genome Sequencing Platform;
RG   Broad Institute Microbial Sequencing Center.;
RA   Champion M., Cuomo C., Ma L.-J., Henn M.R., Klein B., Goldman B.,
RA   Young S., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Heiman D.I., Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S.,
RA   Galagan J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Blastomyces dermatitidis strain SLH14081.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W.,
RA   McEwen J.G., Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01032};
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DR   EMBL; GG657450; OAT05613.1; -; Genomic_DNA.
DR   EMBL; GG657450; OAT05614.1; -; Genomic_DNA.
DR   RefSeq; XP_002627307.1; XM_002627261.1.
DR   EnsemblFungi; OAT05613; OAT05613; BDBG_01978.
DR   EnsemblFungi; OAT05614; OAT05614; BDBG_01978.
DR   GeneID; 8510324; -.
DR   Proteomes; UP000002038; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002038};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002038};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    598       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010068401.
FT   DOMAIN      211    598       Peptidase S53. {ECO:0000259|PROSITE:
FT                                PS51695}.
FT   ACT_SITE    287    287       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    291    291       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    501    501       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       543    543       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
FT   METAL       544    544       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       576    576       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       578    578       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
SQ   SEQUENCE   598 AA;  64911 MW;  2C8BBF81D9E3AA14 CRC64;
     MRAFLLGFIG ASTLVLPALT FPNPLPARCD IVEWLPSVPP GWKQQEAPPP NTLIQFRLAV
     TQENGWLFEQ AVLDLSTPGH PTYGKYMKRD QVQKFLKPLP QVSESILSWL ERGGVSKTAI
     ADHGDWINFK ISVAQAERLL QTKFFYFYNP TRGTRVIRTL EYCVPPEIFP YVHMIQPTTR
     FSQLRPDATS ASALQLVEPD EPYPPVNCSL AVAPACIREM YNMGNFTATP DPRNKLGVSG
     YLEQYARYSD LDLFFQLYAP ELEGSCFDVV SINGGLNLQN SSLSSTEASL DIQYALGLSN
     ATTVYYTTGG RGPMVPDLDL PDPNANTNEP YLDQLHYLLS LPDEELPAIL TTSYGENERS
     VPERYANSTC NLFAQLGARG VSVLFASGDY GPGSACQSND GKNTTQFDPV FPAACPFLTS
     VGGTQGANPE TAIYFSSGGF SDRYSRPAYQ DEAVSAYLAQ LGNKWEGLYN PAGRGFPDVA
     AQSAQFHIID HGRPIYASGT SASAPVFAAV VANLNSIRLA HGKPVLGFLN PLLYSLKGVG
     LNDIVEGYSE GCTGISKLSG LDAPYIPGAG WNATTGWDPV TGLGTPNFAL LAEIVKVL
//
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