ID A0A179UFK4_BLAGS Unreviewed; 1274 AA.
AC A0A179UFK4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Patched sphingolipid transporter {ECO:0000313|EMBL:OAT05781.1};
GN ORFNames=BDBG_02112 {ECO:0000313|EMBL:OAT05781.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT05781.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR EMBL; GG657450; OAT05781.1; -; Genomic_DNA.
DR RefSeq; XP_002627441.1; XM_002627395.1.
DR AlphaFoldDB; A0A179UFK4; -.
DR STRING; 559298.A0A179UFK4; -.
DR GeneID; 8510249; -.
DR KEGG; bgh:BDBG_02112; -.
DR VEuPathDB; FungiDB:BDBG_02112; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002038};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1274
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008107344"
FT TRANSMEM 267..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 745..770
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 829..853
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1071..1094
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1101..1121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1127..1152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1173..1202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1214..1237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 596..770
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1274 AA; 139697 MW; F3295F83D0F7C643 CRC64;
MRLGCLSLLG VLVVAQSNSV FAQGETKIHE EGRCAIRGHC GKKSFFGGEL PCPDNGLAKA
PAAETRRKLV ALCGDKWKTG NVCCEDTQID ALSSNLKMAE GIIASCPACK ENFFNLFCSF
TCSPDQSLFI NVTQTDKVKG KKVVTELDNL WSEVYQVGFY GSCKDVKNGA SGGKAMDFIG
GGAKNYSRFL KFLGDKKLLG SPFQINFVTE PNGPGDVGMR PLPEIPKSCS DSDQKYRCSC
VDCPAVCPRL PALEEESYCH VGHLPCLSFS VIIIYSVFLL LLVAGTLGHF VFQRRQQRKL
ERARLLQDTS PSDDEDEGDL IDDAGILDRP QTSYKLNSVF DAIFNRLGGA CARFPALTIT
TSIIFCGVLS LGWLRFAVET DPVRLWVSPS SAAAQEKAFF DENFGPFYRA EQAFLVNDTH
PNGPGPVLSY ETLSWWFDVE SRVRRMISLD KGLSLDDICF NPTGKACVVQ SLTGYFGGSF
SNVDPNTWED HLRHCTESPG AVDCLPDFQQ PLKPEMILGG YGRPGNVLNA SALVVTWVVN
NHAPGSKAEA GAIDWEDSLK RVLEVVQEEA TEHGLRVSFN TEISLEQELN KSTNTDAKIV
VISYIIMFIY ASLALGSTTL TWKSIIRNPA NSLVQSKFTL GIVGILIVLM SVSASVGLFS
AARIKVTLII AEVIPFLVLA IGVDNIFLIV HEFERVNGSH PDEEIDERIA RALGRMGPSI
LLSATTETIA FAMGAFVGMP AVKNFAAYAA GAVFINALLQ VTMFVSVLAL NQRRVESLRA
DCLPCLTVRK ANSSSIPGGQ PYDHAEEGAL QRFIRKIYAT RLLQKQTKVL VMVVFLGIFT
AGLALLPTVA LGLDQRIAIP NDSYLIDFFN DLYDYFGTGP PVYFVTRDVN VTARHHQKQL
CGRFSTCDGF SLGFVLEQES KRPNVSYISG SAASWVDDFF YWLNPHQDCC KEDGKICFEG
RDPPWNISLH GMPEGSEFIH YAEKWLKSPT DESCPLGGLA PYSNALVLDS KHVTTNASHF
RTSHTPLRSQ KDFIKAYESA RRIADDISQK HDIDVFPYSK FYIFFDQYAS IVRLTGTLLG
SATAIIFVVT SVLLGSIATG AVVTATVIMT VVDIIGAMAI ANVSLNAVSL VNLIICVGIG
FEFCAHVARA FMFPSSPLLE QARDKFRYRT ARAWVALVNV GSSVFTGITV TKLLGVCVLA
FTRSKIFEIY YFRIWLALVI FAASHALIFL PVALSFFGGD GYCDPQTDGG LEGDLAARRY
RSLLPDDYDS EDDS
//
