ID A0A179UH89_BLAGS Unreviewed; 937 AA.
AC A0A179UH89;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=DUF221 domain-containing protein {ECO:0000313|EMBL:OAT07354.1};
GN ORFNames=BDBG_03425 {ECO:0000313|EMBL:OAT07354.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT07354.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; GG657452; OAT07354.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A179UH89; -.
DR VEuPathDB; FungiDB:BDBG_03425; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF53; DOMAIN PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 39..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 673..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..190
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 213..407
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 419..692
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 840..929
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 937 AA; 105540 MW; A00416ECE35D20A5 CRC64;
MSELLDPNND PNIGSSRGEN QSTIDVTLGS LGVDTSTSAA ALLTTFVPAF VLFTLWTAVF
IICRRSQQRF YAPRSYLGNI HEHERSPELP SGWVNWIGAF FNLSDTYVLQ HSSLDGYFFL
RFLRLMSVTC FVGCLVVWPI LFPIHATGGA GNTQLDALSF SNVKDPNRYY AHVFVAWMFF
SFIFYMVTRE SMFYATLRQA YFLSPLYASR ISSRTVLFMA VPQTLLTKSK MAKVFGKSIR
RIWITTDCKK LDERVKERDE LALKLESLET DLIKSANSAR SKAMKKQKRD EECVVDTGPN
PDGMACDLDS IPWAKRVKRP THRLRYFTGE KVDTIEWLRS ELEKVLPKVE KLQKKHRDGD
AKSIPAVFIE FDSQAAAQTA YQMLSHHQPF QMTPRYIGIT PQEIIWPALQ YSWWQRIVRK
FLIQAAITAL IIFWSIPSAF VGMISNVAYL SNLLPFLGFI NELPEVIKGV ISGLLPAVGL
ALLMALVPIL LRFLARQTGL PTTVHVELFT QNAHFCFQVV QVFLVTTLTS AASAATSQII
KDPMSAKDLL AKNLPKASNF YISYFLLQGL VLSAGAVVQV LGFVIFKIFV AFFDTTPRKL
YERWTSMNGL RWATVFPVFT NMVVIAITYS CIAPLILGFS SFGLYLVYQA YRYNLLFVYD
SDVDTKGLIY PRALQQVLTG VYLSSVCMIG LFAIKGAIGP VIMMVLFIIL TILAHISLND
ALRPLLSALP RTLEQAEMLG DNDAHDDDDG SFGEQDDSSS NSHDGTTGEK PPVSPESASN
EIPSPISAYK LKSSTQTTIT LAEITRAGTS AETPVFPHHR PNALHAILRK FSYFIHSIVE
PHIYIDYATL RKRIRQGTPV EYTDEVADNA YYPPSVWSPT PLLWVPRDAG GISQREVELT
SRVIPMTDEE AHLDERNKVK WDQVKSQPPI WQEKIFY
//
