ID   A0A179UM49_BLAGS        Unreviewed;      1086 AA.
AC   A0A179UM49;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   08-NOV-2023, entry version 22.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   ORFNames=BDBG_04190 {ECO:0000313|EMBL:OAT08217.1};
OS   Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT08217.1, ECO:0000313|Proteomes:UP000002038};
RN   [1] {ECO:0000313|Proteomes:UP000002038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR   EMBL; GG657454; OAT08217.1; -; Genomic_DNA.
DR   RefSeq; XP_002625321.1; XM_002625275.1.
DR   AlphaFoldDB; A0A179UM49; -.
DR   STRING; 559298.A0A179UM49; -.
DR   GeneID; 8504804; -.
DR   KEGG; bgh:BDBG_04190; -.
DR   VEuPathDB; FungiDB:BDBG_04190; -.
DR   OrthoDB; 38995at2759; -.
DR   Proteomes; UP000002038; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002038};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          39..77
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   DOMAIN          40..297
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          543..1017
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   1086 AA;  119529 MW;  CC925F148FCDB822 CRC64;
     MSELQDFLLV VENNREEALG IASITAQKLE SKQSTLIDVV QSLGEYINDE NPIIRGKAVS
     YLTAVIRALS PKLLSRQQIQ ALTDFYCDRI ADGGAIAGLD RLQGLERFTK DMTEGVIRSI
     FQHFPDLQAR PQSQRFQLLQ LLNGLMSNHR KALRDMGDES LVGIVDLVSG ERDPRNLMLI
     FSILRVLMVE WDITKNVQAL FDSVYNYFPI TFKPPPNDPY GITAQDLKTR LQDCISSTQL
     FAPYAFPSLL DKLDSTSLNV KKDALNSLYA CISSYDPATL SRYSISVWDT LKFEILNAQE
     EIITEESLRV LQCLAKRLST LTTTSQISAL AQYLKPITKE CNEQLREPQQ KQAQPARQIL
     RSLSSASLAS FALIIQAVVA PLLAVYQDAD GIAKQRALLE SFVVLFDSAI DIFGTWTTPG
     SDPAPENPLS SFQERLIEIF SQALMGSAKD ETSFRLTSLQ GLLRLSSIRG FLQENEIGLF
     VQYLDDILLI ETSVRAELRK AAIDALAGIS KHKPRLIMDI AFPAFMATLP DSDKDADPVY
     LTTLESLAQI SIEKDIFETF VRRLLSRLEI VLQLGNTSTS AYPRAILLTI LYAMDRKGLQ
     NDSNITYYYD QILVKLTRRA ALATTEDDTT TVMKDSSLLD VLGRLCNLIV RSLPREKQDE
     VCGNVYALFA TDDSFIPIPF SSTTTYLREQ TMILSTYLLA GLPKDSKLPY TSPDMESLLQ
     ELVRRAIAEE NLTTHLALAR HLALLVNKFL PTTQVPTASS ILSALIQSST STSKPTPNEA
     FTSPKIRTIF WLAKALILRL APSTAEILNS LLALLSSSDA QTSTTSGRGF ALLLSPDDVL
     SPQNGAVIRL LSKQRVFSTL IPLISQNVRD LNTGATAASR VPLHTKQAYL TALSGILSTI
     PSSLVMPELP TLLPLLLQSL DLTDPLSQPI KAGTLETLAV IIRDNGVSVI NEVGYVDDLV
     KRLLKTAVYN KNTAASTSTT VTKETTTAAT SANDTSTSVP NTPHIRAQSL QCLLLLAQTP
     GVSDSTSPAA KAASAKPSPL LPLKHVVLRT LRFALDDPKR DVRKAAVDAR AAWLRGVVDV
     EEDEED
//