ID A0A179UMU7_BLAGS Unreviewed; 371 AA.
AC A0A179UMU7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Threonine aldolase {ECO:0000313|EMBL:OAT07732.1};
GN ORFNames=BDBG_03767 {ECO:0000313|EMBL:OAT07732.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT07732.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the threonine aldolase family.
CC {ECO:0000256|ARBA:ARBA00006966}.
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DR EMBL; GG657453; OAT07732.1; -; Genomic_DNA.
DR RefSeq; XP_002625708.1; XM_002625662.1.
DR AlphaFoldDB; A0A179UMU7; -.
DR STRING; 559298.A0A179UMU7; -.
DR GeneID; 8509834; -.
DR KEGG; bgh:BDBG_03767; -.
DR VEuPathDB; FungiDB:BDBG_03767; -.
DR OrthoDB; 178754at2759; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:InterPro.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR CDD; cd06502; TA_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR023603; Low_specificity_L-TA-like.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; NF041359; GntG_guanitoxin; 1.
DR PANTHER; PTHR48097:SF9; L-THREONINE ALDOLASE; 1.
DR PANTHER; PTHR48097; L-THREONINE ALDOLASE-RELATED; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR PIRSF; PIRSF017617; Thr_aldolase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002038}.
FT DOMAIN 12..293
FT /note="Aromatic amino acid beta-eliminating lyase/threonine
FT aldolase"
FT /evidence="ECO:0000259|Pfam:PF01212"
FT MOD_RES 208
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR017617-1"
SQ SEQUENCE 371 AA; 40428 MW; 31E169830BAD3AE8 CRC64;
MSNPKVSRAA NDFRSDTFST PTPAMLQAMM NATFGDDVYQ EDSTTTEFEN EIARLTGMEA
ALFTLSGTMG NQIGVRVHLE KPPHSILCDY RAHVYAEEGS GLAILSQAMV TPVHPANGIY
MTLSDVKRWV TLGDDVHTAP TKVISLEITI GGVLTPMEEI RKISEFARAN GIKVHCDGAR
LWNASVATGH SLADYCQYFD SVSMCVSKGL GAPIGGVLAS TKANIKHARW LRKQQGGGIR
QASILTAAAL VALNEVWPTM KETHEKTKKL AKDLETLGVV PQIPVDTNFY FIDAGKSKID
MGVLLEQCQK FNVKLMDERI SMHHQISDEA IENLKAAIAA AVEITNTLSP DYVSTAQTGV
YAITSKMNEY N
//
