ID A0A179UN43_BLAGS Unreviewed; 753 AA.
AC A0A179UN43;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 23.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN ORFNames=BDBG_03861 {ECO:0000313|EMBL:OAT07832.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT07832.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|EMBL:OAT07832.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SLH14081 {ECO:0000313|EMBL:OAT07832.1};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center.;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I.,
RA Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S., Galagan J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Blastomyces dermatitidis strain SLH14081.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR EMBL; GG657453; OAT07832.1; -; Genomic_DNA.
DR EMBL; GG657453; OAT07833.1; -; Genomic_DNA.
DR RefSeq; XP_002625802.1; XM_002625756.1.
DR AlphaFoldDB; A0A179UN43; -.
DR STRING; 559298.A0A179UN43; -.
DR GeneID; 8505214; -.
DR KEGG; bgh:BDBG_03861; -.
DR VEuPathDB; FungiDB:BDBG_03861; -.
DR OrthoDB; 1065060at2759; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF187; SODIUM/HYDROGEN EXCHANGER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Ion transport {ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002038};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003722}.
FT TRANSMEM 35..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..457
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 516..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..621
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 753 AA; 81488 MW; 17A22BF7EC3D6EB9 CRC64;
MAEFIRDVLV DGLRKRAEDD TDPDESPEAG EKELFTSWAL FILIMLLITA LFTSYILQQR
KVQAVHETVI SIFAGMVVGL IIRLSPGTLI QSSVSFDYQF FFNLLLPPII LASGYELHQA
NFFRNIGTIL TFAFAGTFIS ALVLGLILYL WSLIPLDGLS ISFVEAFSVG ATLSATDPVT
ILAIFNVYKV EPKLYTVIFG ESILNDAIAI VLFETAQRYR PGRAAGSLTL ISLFEAVGVF
LLVFFGSLVI GVAVGMLTAL GLKYTRVRRE PKIESCLIVL IAYASYFFST GVHLSGIVSL
LFCGITLKHY AYYNMSRRTQ LTTKYLFQVL AQLSENFIFI YLGLDLFTEP NLQFKPLFIM
IAVVGICVAR YMSVFPLSKA INWFIRYRAR RRGREVADEL PVAYQGMLFW AGLRGAVGVA
LAAGLEGPNA PALRATVLVV VVLTVIIFGG TTARMLEILE IRTGVVEEID SDDEFDIEIT
TGGTYYKHDG TGVGHIPRRN GYTVPLDTMN LDREDVAEGY SSGNNGSIAP RRTHSSIAAR
KQAVYGQSRS ELSRDHASTQ NLLANHNGNK NGSASGSSAD DGDVSRNSPF PNRPRPRVRN
GGTQENDADI DDFELDLDTF SDDDLPPAAP SRSGRAQPGG AVSSSSTPTV TSAQQRVSPA
RAAPLGAGAG FPGGGEGIGT SGILAEASRG AAGSSSSPRP GATDVIRDLF SGGANVDHAA
WFRQLDEDYI KPKLLLDPGS GHHHRNHKGP GAV
//