ID A0A179UQ67_BLAGS Unreviewed; 455 AA.
AC A0A179UQ67;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=NAD-dependent histone deacetylase SIR2 {ECO:0000313|EMBL:OAT10225.1, ECO:0000313|EMBL:OAT10226.1};
GN ORFNames=BDBG_05892 {ECO:0000313|EMBL:OAT10225.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT10225.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|EMBL:OAT10225.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SLH14081 {ECO:0000313|EMBL:OAT10225.1};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center.;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I.,
RA Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S., Galagan J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Blastomyces dermatitidis strain SLH14081.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
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DR EMBL; GG657459; OAT10225.1; -; Genomic_DNA.
DR EMBL; GG657459; OAT10226.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A179UQ67; -.
DR STRING; 559298.A0A179UQ67; -.
DR VEuPathDB; FungiDB:BDBG_05892; -.
DR OrthoDB; 5488599at2759; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002038};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 183..302
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
FT REGION 410..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 51352 MW; 7B527A87C45FDE71 CRC64;
MEYLIRFAQV HESFRKPEIE ALAALVGTNV EFLAYAENTP FAVVKLQDEA AARAVICRSI
LAKGIYEIWG HGKTYEELHM DIRNRTEARW NNFKSKSFKF SVDSYAGKRS ANEKTQIIHS
FAYMGFQGPI RMTDPDEEFC IFEEYPCRPI KPGEARPGPN FVHFGRWIAC GSRDVIDKYD
LKKRNYISTT SMDAELTLVT ANMALAAPGK VFFDPFVGTG SFCVAMAHFG THSLGSDIDG
RSFSGKDRKK GKSIGLVSNL EQYGIQQYHL DAFVSDLTNS PIRSTPFLDG IICDPPYGVR
EGLKVLGSRY GKKKEPFFLD GVPSHSLDGY IAPKKPYSFD AMLDDILDFA ARTLVQDGRL
SLWMPTANED DVELKIPSHP RLELVSVCVQ PFGHWSRRLL TYRLLPDGEF SSSEPRRQRE
EINGVNADDL NSFRRKYFTK SKPSPTDSPD NKTPQ
//