ID   A0A179URQ9_BLAGS        Unreviewed;       996 AA.
AC   A0A179URQ9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=von Willebrand domain-containing protein, variant {ECO:0000313|EMBL:OAT10795.1};
GN   ORFNames=BDBG_06588 {ECO:0000313|EMBL:OAT10795.1};
OS   Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX   NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT10795.1, ECO:0000313|Proteomes:UP000002038};
RN   [1] {ECO:0000313|Proteomes:UP000002038}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
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DR   EMBL; GG657461; OAT10795.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A179URQ9; -.
DR   VEuPathDB; FungiDB:BDBG_06588; -.
DR   OrthoDB; 4178950at2759; -.
DR   Proteomes; UP000002038; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR45737; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A; 1.
DR   PANTHER; PTHR45737:SF6; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN DDB_G0286969-RELATED; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF13768; VWA_3; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002038}.
FT   DOMAIN          11..142
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          293..461
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          493..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          688..729
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          750..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        506..520
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        709..724
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        766..794
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   996 AA;  108634 MW;  67ADD114A9A098C8 CRC64;
     MSRRPNHLLP KCGCWYSASG TRQYIPQVDL KAHSTILSTS SRTTLTQTFI NPTSGELGDV
     KYTFPLHDGV SVVGFKCEID NRVIHGLVKE RQEAKLEYQD AVKKGQAAAL LEQSALASDT
     FTTSIGKIPV GSKAVVQITY LGELQHDSQA DGVRFSIPAI ICPRYANSSV DTGELSQSLA
     SFVKKGAINI TVDVSVDRGS TIRGLHSPTH PVAITLGRTS VAAQDLFEPN LASAAHTMQQ
     GNAFFDTDFV LIVNAKDQDV PSAFVEKHPT IPNQRAVMAT LVPKFNIPNN NPEIVFIIDR
     SGSMTGNIKT LQSALRVFLK SLPVGVKFNI CSFGSRHSFM WNKSKTYDAS SLKAALQYVD
     SIAADFGGTE MLEPVKATVK NRLKDLDLDV LLLSDGEIWD QKTLFAYLNE VVSEQPIRLF
     SLGIGSGASQ SLIEGIARAG DGFAQFVGDN EQLDKKVVRM LKGALTPHIK DYTAEIVYEN
     DGEEDFELIE KPNAIPTGEN FGRPAERSAE PIEVDAQKET PQSKEPISLF DPSYQEPDIK
     SITVPLDANL PKLQPPKVLQ APYKIPTLYP FTRTTVYFLL SPDAPSAALK SLVLRATSKH
     GPLMLKIPLE DIGQGTKLHQ LAARKVTLEL EEGRGWIYHT KNEKGQLIVN EHESKKEDIV
     KREAVRLGIQ FQVAGKYCSF VAVESTTDGG KADKKAEAGL PGIRNHPISE TAGDRDHTDD
     EESFDGDTGF VMDYDQEEYT EELCTMPRYS TMSDSPLGEP LASGGFGSPF STSSSSHTQS
     RFAAPPQSAS TRLFGSAPPP PGQATSSPFG PPAVSTSSGI DIPLKRGERL DGIVSKSDDL
     AKSANVFARK RSSVVPSAKQ KLARFFKSES EPKESKSPQD KVHALISHQS FEGSWMWEDN
     VFAIMDLNAS EAEKKLDWAA ILGKQSGVGS KDTKQRSIVA TLVVLAYLKK KCLDEKDTWE
     LVGDKAMGWA VERIKEIGGN AGQGSDELLR LFDGLF
//