ID A0A179UVV7_BLAGS Unreviewed; 624 AA.
AC A0A179UVV7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Dioxygenase {ECO:0000313|EMBL:OAT12236.1, ECO:0000313|EMBL:OAT12237.1};
GN ORFNames=BDBG_07612 {ECO:0000313|EMBL:OAT12236.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT12236.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|EMBL:OAT12236.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SLH14081 {ECO:0000313|EMBL:OAT12236.1};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Microbial Sequencing Center.;
RA Champion M., Cuomo C., Ma L.-J., Henn M.R., Klein B., Goldman B., Young S.,
RA Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Heiman D.I.,
RA Hepburn T.A., Saif S., Shea T.D., Shenoy N., Sykes S., Galagan J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Blastomyces dermatitidis strain SLH14081.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC {ECO:0000256|ARBA:ARBA00006787}.
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DR EMBL; GG657466; OAT12236.1; -; Genomic_DNA.
DR EMBL; GG657466; OAT12237.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A179UVV7; -.
DR STRING; 559298.A0A179UVV7; -.
DR VEuPathDB; FungiDB:BDBG_07612; -.
DR OrthoDB; 294919at2759; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR InterPro; IPR004294; Carotenoid_Oase.
DR PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR PANTHER; PTHR10543:SF24; CAROTENOID ISOMEROOXYGENASE; 1.
DR Pfam; PF03055; RPE65; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000313|EMBL:OAT12236.1};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR604294-1};
KW Oxidoreductase {ECO:0000313|EMBL:OAT12236.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002038}.
FT REGION 20..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 245
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 295
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 369
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 609
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ SEQUENCE 624 AA; 68334 MW; A3B0684C4A627218 CRC64;
MTSSLRQVVS SRKRLTQITT AHTMGAVDTS TKSSNDWPNH QGFNSTYEER TPVELKVTGD
IPAWAAGVLY RTGTGRSEIE TDQRQTFKVA HWFDGLAVVH RFQILPPDAT HPSVRVFYNS
RSCCDGLIER IRKTGKGNEM SFAAKYDPCT SYFQKAMSLF RPAPPKTPGA DQQSMSITLS
VNFPGLSSST TTQKTSGHAS GIHTLTNKTD AAVFQTLDPE TLEPIGLASQ QVLHPALKGP
ISAAHAKSDP ATGDVYNFNL ELGKCPIYRI FHVSAATGKT SVLATLTNAR AAYLHSLFLT
EHYVILCVWN SYFTAGGLAI LWHKNIVDAI ADYDPSKKST WYVIDRRPTD QGGRGLVATY
KSDPFFCFHT VNAYEEPSPD GSGDIDIVAD LTTYNNLDII KRFYLSNIVS TSPNAAKYAA
GIDPASRAIY KRFRLPSVPV PSPSSSTPTP SKASKPKRAI LDFKNEAANT PELPTLNPHY
VTRRHRYVYG VTDSGKSSFL DGLVKVDTET KQTIHWKEWG QNPGEPIFVQ RRIIPRQEGE
SGSENDSEDA VGEVEKEVDA DVFDEDDGVL LSVVLDGLKG KSYLLVLDAK NLKEVGRAEV
AGPIGFGFHG THVSAMSGGR GLDY
//
