ID A0A179UXR8_BLAGS Unreviewed; 570 AA.
AC A0A179UXR8;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=NEDD8-activating enzyme E1 regulatory subunit {ECO:0000256|PIRNR:PIRNR039099};
GN ORFNames=BDBG_07929 {ECO:0000313|EMBL:OAT12603.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT12603.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- FUNCTION: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.
CC {ECO:0000256|PIRNR:PIRNR039099}.
CC -!- PATHWAY: Protein modification; protein neddylation.
CC {ECO:0000256|ARBA:ARBA00005032, ECO:0000256|PIRNR:PIRNR039099}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. ULA1
CC subfamily. {ECO:0000256|ARBA:ARBA00006868,
CC ECO:0000256|PIRNR:PIRNR039099}.
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DR EMBL; GG657468; OAT12603.1; -; Genomic_DNA.
DR RefSeq; XP_002621711.1; XM_002621665.1.
DR AlphaFoldDB; A0A179UXR8; -.
DR STRING; 559298.A0A179UXR8; -.
DR GeneID; 8508729; -.
DR KEGG; bgh:BDBG_07929; -.
DR VEuPathDB; FungiDB:BDBG_07929; -.
DR OrthoDB; 5488891at2759; -.
DR UniPathway; UPA00885; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0019781; F:NEDD8 activating enzyme activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045116; P:protein neddylation; IEA:UniProtKB-UniRule.
DR CDD; cd01493; APPBP1_RUB; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR030667; APP-BP1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953:SF29; NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR Pfam; PF00899; ThiF; 1.
DR PIRSF; PIRSF039099; APP-BP1; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002038};
KW Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR039099}.
FT DOMAIN 19..563
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
FT REGION 460..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 570 AA; 63052 MW; DC5B2ED858058B3F CRC64;
MTESFPSSLA GLTSKERKYD RQLRLWAASG QKALENSKIL LINSDGPLDN EYPAVPGAVG
VETLKNLVLP GVGGFTIVDP AIVTESDLGV NFFLDEGSLG KSRAKETCKF LLELNPDVEG
DSLDKPIEEL LKEENFLKQY SLIVITAPMR RSMLKTISAA ARQRVIPLIY THSVGFYSGF
SLQLPTVYPI VETHPDPNSV QDLRLTNPFP ELVAATAKIA DLDSLDDHDH GHVPYLLLLL
HFLEKWKATH DGNLPLSYKD KSAFREMVRD GARTNNSTGG EENFDEAVAA VLKSINPWSL
KSNVREMFDM EQCNNLNPKS DNFWIIASAI KSFYTTHGVL PLPGSLPDMK AQSADYISLQ
NIYKSKALKD LEEVVGSVRA LEAQLRGESP QPPIPEKEIE TFCKHASSVK VIRGRDIPIL
DSNTDPITLK AIRQAFQHPD SLMPIFLTLQ ILDTLVSEYR EKASEPQPEP PSSSSPPFLD
QADNWAGAQS KLFALLETDG YTLDDDVKLR IAKAMQETQR AGVGELHNIS SLTGGMVAQE
ALKVLTRQYV PLDNTCIFDG IGSRAEMFRL
//
