ID A0A179UY21_BLAGS Unreviewed; 898 AA.
AC A0A179UY21;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Chloride channel, other eukaryote {ECO:0000313|EMBL:OAT12740.1};
GN ORFNames=BDBG_08051 {ECO:0000313|EMBL:OAT12740.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT12740.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG657469; OAT12740.1; -; Genomic_DNA.
DR RefSeq; XP_002621428.1; XM_002621382.1.
DR AlphaFoldDB; A0A179UY21; -.
DR GeneID; 8508670; -.
DR KEGG; bgh:BDBG_08051; -.
DR VEuPathDB; FungiDB:BDBG_08051; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF3; CLC CHANNEL; 1.
DR Pfam; PF00654; Voltage_CLC; 2.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002038};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 188..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 898 AA; 98772 MW; 3AC319D3AD1781A7 CRC64;
MTPALQRSVS NASGLGGDDD DSTSDQDDNP RLIVTSPPSP TSRREQTTRF AELDIRSRLP
RRPTTTDMDE RTGLLGAADD SNRTYTTIPN SASSTRPPPF HRHPSTAGSV RIPRNHSRAN
SQAVKFGGRD WSHTDTGDYS SKNSLGASFL DDRVWYDQFT STDWVHDSIA DGIRLRQLRS
RRDIRGRLLA WADGAQGWIL VAVIGCLTAC VAYFVDVTEN AMFDVKEGFC TENWFFSRRR
CCLPEEQECD AWLSWAEILE SSPIDRKWID FVAFVFWAVV LAACSCVLTL LTKTVVPSSV
SLSTLDEDLG AEIESPGDSP IRDRKTSSSS QSPQRGIVAA PPMVYYSAAG SGVAEVKVIL
SGFVLHGYLG FKTLVIKTLA LVLAVASGLS VGKEGPYVHI ASCIGNISCR IFSKYHHNDG
KRREVLSASA ASGVGVAFGA PIGGVLFGLE EVSYYFPPKT LFRTFFCCIA AALSLKFLNP
YGTGKIVLFE VRYVSDWKVF ELLIFMLLGV LGGASGALFI KASKLWAQSF RRIPVIKRWP
LLEVVLVSLI TGLVSFWNRY TKLPVSELLF ELASPCDPDT ESRTGTLPHG RQDPRVPAGI
YVPSMVVGGL LGRIVGHIAQ YFVVHFPDSF LFGSCSSSRD ALSCINPGVY ALIAAGSTMC
GVTRLSVTLV IILFELTGSL DHVLPFSLAI LCAKWTADAM EPLSIYDLLT DMNSYPYLDN
KLHPTSDIEL SELVPRVRKN RIIDISNSPL VPATELRQKL DVLLLAGELD GGLPILRKNI
LVGLIPAPEL EYALDRLEDE EEAMCLMCID SSYEGWSAEG DRDRERVDST GRMADFTPFI
DPAPVALDIH SPISLVYQCF VKLGLRYMCV LRDGQYAGLV HKKSFVKFMK EQGKGTHK
//
