ID A0A179UYX5_BLAGS Unreviewed; 843 AA.
AC A0A179UYX5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Forkhead transcription factor HCM1 {ECO:0000313|EMBL:OAT12307.1};
GN ORFNames=BDBG_07666 {ECO:0000313|EMBL:OAT12307.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT12307.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG657467; OAT12307.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A179UYX5; -.
DR STRING; 559298.A0A179UYX5; -.
DR VEuPathDB; FungiDB:BDBG_07666; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00059; FH_FOX; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11829:SF343; FORK HEAD DOMAIN TRANSCRIPTION FACTOR SLP1-RELATED; 1.
DR PANTHER; PTHR11829; FORKHEAD BOX PROTEIN; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000002038}.
FT DOMAIN 268..362
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 268..362
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..45
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 93019 MW; 96817DCB51A91644 CRC64;
MASTRQPPPL RIYQDSGPLP HPHPHPHPHP HPHPQPHHPH QHPHQHPHPI TTPSMTQPPN
TQSASSNLPH QPNRLQPSPM PLQPMRNASI NKNLALTPTT NGQSNVSPVK PQRRPSMSAP
GANHHHHHHH RDKLSFVPIS APHPVAFTTD SPTKHSRANG STYSQSAPPP IAQHALFTTF
SSIPTTDHSH GSRAHSISAQ HEKKLSNTPA FHQRPSAYAG PTPAKRTLME PAPLSKDRPS
KKPKREELSF VQLPDPRDMP RIEDDGAKPP YSYAILIGMA ILRAPNRRLT LAQIYKWISD
TFAFYRAGDS GWQNSIRHNL SLNKAFIKQE RPKDDPGKGN YWAIEPGMEA QFLRDKPARR
NLVAALSQPT PRPEPRIELQ PRLYPTPIAA NRATTTTTAT PDAINITAAN TTNTTTTTTT
TTTTTNNSTN TSAPASNHSA TATITNSSYM LPPTGQPSNR AVNIDLSSDA TLPASDPALQ
EDSGDEVERL AMHHSTRLPL SSPPPIHSSP PIAPSVFHRQ ATPPTPSRPL TGSAAIPLSR
KRSSAAMNDS GYYSSLESSA MRPHKAGHIL TSDLDIEPPR IKRGRAEEEI ARIRSSSHDI
SPLRIGTLKD TTQLIGSSPL RHGYNNMLPP PITPAIKFKK PTKPPPSLSP NTNLQNHRKK
IQQMVNSPIK QYGLTDDILP WSPAFNIQDD AFLSNDNLNI PFDIFAEQFP TTISTPSHGS
PEKRSARRPR FDRSSNMLAD ITDLHGNNRL NTPTLKSSKV RGLKYHESPS KKPNTPQFND
VSQDDLFSFN LFSEDTAEVD GIDLLQGFEK IGQSGKDDYS PKQLLQNRSY FGSRSINNNN
PRF
//
