ID A0A179V1I4_BLAGS Unreviewed; 620 AA.
AC A0A179V1I4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 08-NOV-2023, entry version 24.
DE RecName: Full=RNA-binding protein VTS1 {ECO:0000256|ARBA:ARBA00024136};
GN ORFNames=BDBG_09004 {ECO:0000313|EMBL:OAT13893.1};
OS Blastomyces gilchristii (strain SLH14081) (Blastomyces dermatitidis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Blastomyces.
OX NCBI_TaxID=559298 {ECO:0000313|EMBL:OAT13893.1, ECO:0000313|Proteomes:UP000002038};
RN [1] {ECO:0000313|Proteomes:UP000002038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SLH14081 {ECO:0000313|Proteomes:UP000002038};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- SUBUNIT: Monomer. Binds to RNA. {ECO:0000256|ARBA:ARBA00024046}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the VTS1 family.
CC {ECO:0000256|ARBA:ARBA00007325}.
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DR EMBL; GG657480; OAT13893.1; -; Genomic_DNA.
DR RefSeq; XP_002620593.1; XM_002620547.1.
DR AlphaFoldDB; A0A179V1I4; -.
DR STRING; 559298.A0A179V1I4; -.
DR GeneID; 8501258; -.
DR KEGG; bgh:BDBG_09004; -.
DR VEuPathDB; FungiDB:BDBG_09004; -.
DR OrthoDB; 1351201at2759; -.
DR Proteomes; UP000002038; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:InterPro.
DR CDD; cd09556; SAM_VTS1_fungal; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037635; VTS1_SAM.
DR PANTHER; PTHR12515:SF5; PROTEIN SMAUG; 1.
DR PANTHER; PTHR12515; STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002038};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 552..610
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..284
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 67150 MW; B53D74DEAB4AB297 CRC64;
MASHIIGNRN STPEASKSSL RPPSSRALGG SHQLRASADM SSFASPLSAR SIRPSSEVFY
NQQSHSQNND DIDKAAQQWI ADIDQYETTL EEMAAATLDQ DFKDELSAIE QWFRVLSEAE
RTAALYALLQ QTTQVQIRFF IQVLQQMSKS HPMSSVLSPA NFGEKDPMNN RLTDAMSKLN
VEGSRNSFSR PPLSPGNKRN SGLDSSTINA MFPDAAAAIA KQKAEFTQQT GTAPSANRNS
AVFGDRSSLI APTISAPDSG KDNLPQPPSS PWIQRTPEPQ PPIARPKSSS GQQHPPMGQF
VQPPQSAGLR SPRSMPPGPS NIQSTIVTAP DLSTEPHFFS PYNGASWASM TNTPNVAAFN
QQQNAPSQAD MVANATAMKL AALSTVNNRI ALDDARKYRR ARSNDGQGKS PNMNQQPLSP
GIPNNNLPGT NLIMVNDVGQ ILNAQQIAAL QAQQQAAMAG RRSRPNSPGI AMQGGGMGHM
TFAPPQNNGF LAAYDTNALL NNGFGGLNMA QFSGNPEGYL SDHSEIARGR SPRGRRGSSK
PPEDPTDPHL LQDIPSWLRS LRLHKYTENL KDLKWTELIE LDDKGLEERG VNALGARNKM
LKVFDQVKEA KAEGKLNSAL
//
