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Database: UniProt
Entry: A0A180EKW3_9BACT
LinkDB: A0A180EKW3_9BACT
Original site: A0A180EKW3_9BACT 
ID   A0A180EKW3_9BACT        Unreviewed;       441 AA.
AC   A0A180EKW3;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=3-hydroxy-3-methylglutaryl coenzyme A reductase {ECO:0000256|RuleBase:RU361219};
DE            Short=HMG-CoA reductase {ECO:0000256|RuleBase:RU361219};
DE            EC=1.1.1.88 {ECO:0000256|RuleBase:RU361219};
GN   ORFNames=A3850_002120 {ECO:0000313|EMBL:OAV43364.1};
OS   Lewinella sp. 4G2.
OC   Bacteria; Bacteroidota; Saprospiria; Saprospirales; Lewinellaceae;
OC   Lewinella.
OX   NCBI_TaxID=1803372 {ECO:0000313|EMBL:OAV43364.1, ECO:0000313|Proteomes:UP000076582};
RN   [1] {ECO:0000313|EMBL:OAV43364.1, ECO:0000313|Proteomes:UP000076582}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4G2 {ECO:0000313|EMBL:OAV43364.1,
RC   ECO:0000313|Proteomes:UP000076582};
RA   Wong S.-K., Yoshizawa S., Ogura Y., Tetsuya H., Nakajima Y., Hamasaki K.;
RT   "Lewinella sp. 4G2 Genome sequencing.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-
CC         methylglutaryl-CoA + 2 H(+) + 2 NADH; Xref=Rhea:RHEA:14833,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:43074,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.88;
CC         Evidence={ECO:0000256|RuleBase:RU361219};
CC   -!- PATHWAY: Metabolic intermediate metabolism; (R)-mevalonate degradation;
CC       (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361219}.
CC   -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC       {ECO:0000256|ARBA:ARBA00007661, ECO:0000256|RuleBase:RU361219}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAV43364.1}.
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DR   EMBL; LVWJ02000014; OAV43364.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A180EKW3; -.
DR   STRING; 1803372.A3850_002120; -.
DR   OrthoDB; 9764892at2; -.
DR   UniPathway; UPA00257; UER00367.
DR   Proteomes; UP000076582; Unassembled WGS sequence.
DR   GO; GO:0140643; F:hydroxymethylglutaryl-CoA reductase (NADH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR   GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.8.660; -; 1.
DR   InterPro; IPR002202; HMG_CoA_Rdtase.
DR   InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR   InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR   InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR   InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR   NCBIfam; TIGR00532; HMG_CoA_R_NAD; 1.
DR   PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR   Pfam; PF00368; HMG-CoA_red; 1.
DR   PRINTS; PR00071; HMGCOARDTASE.
DR   SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR   SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR   PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|RuleBase:RU361219};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU361219};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076582}.
SQ   SEQUENCE   441 AA;  48613 MW;  21B248B187AFB9DD CRC64;
     MVAQDQQRIN GFSKFSKEQR RQWLAEQFLE DGAAGTLAKF DFSDEEVQRV FDGFSENTVA
     NFPLPYGVAP NFVVNGRTYV VPMVTEESSV VAAASAAAKY WMTRGGFKTE IVATEKLGQL
     HFRWSGSPER RSALLSELCT RVSAQTKELT ARMESRGGGV RGITWKHLPE VADDCYQLLV
     KFGTADSMGA NFINTVLEAY GQELRRWATT SPSLRESERD LEVIMAILSN HTPNCIVRAW
     VSCPIADMAL PVNGVDPHDF ARRFRYAVEI ARQDPYRAVT HNKGIMNGID AVVIATGNDF
     RAVEAAAHAF AAQDGTYRSL SRCRIEHDHF HFELSLPLAL GTVGGLTKLH PLAKLSLDCL
     GQPSAPELMS VIAAAGLAQN FAAVRSLVTT GIQKGHMKMH LQNILTEFAA TPKEREATVA
     HFADRTVSYA GVRTFLETVR T
//
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