ID A0A180F3M6_9BACT Unreviewed; 881 AA.
AC A0A180F3M6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:OAV66948.1};
GN ORFNames=Barb4_02688 {ECO:0000313|EMBL:OAV66948.1};
OS Bacteroidales bacterium Barb4.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales.
OX NCBI_TaxID=1633200 {ECO:0000313|EMBL:OAV66948.1, ECO:0000313|Proteomes:UP000078495};
RN [1] {ECO:0000313|EMBL:OAV66948.1, ECO:0000313|Proteomes:UP000078495}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Barb4 {ECO:0000313|EMBL:OAV66948.1,
RC ECO:0000313|Proteomes:UP000078495};
RA Tai V., Carpenter K.J., Weber P.K., Nalepa C.A., Perlman S.J.,
RA Keeling P.J.;
RT "Genomic and NanoSIMS analyses of nitrogen-fixing bacterial ectosymbionts
RT of a protist inhabiting a wood-eating cockroach.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAV66948.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LBCX01000181; OAV66948.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A180F3M6; -.
DR PATRIC; fig|1633200.3.peg.1630; -.
DR Proteomes; UP000078495; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000078495}.
FT DOMAIN 702..718
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 510..537
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 628..635
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 881 AA; 98136 MW; F4813D2E75B43010 CRC64;
MTVLFYAKNT VVIRQANDTP LIKQYFTVKA KYPDALLLFR VGDFYEMYGE DAVAGSAIAG
ITQTRKSNGG GQFIEMAGFP HHALDTYLPK LVRAGRKVAI CDQLEDPKAT KKLVKRGVTE
LVTPGISVND AVLNRKENNF LAAVHFGKDC CGTAFLDIST GEFLTAEGTA DYIDKLLNNF
SPKEVLVEKT NRKLFEETFG LRFLLSGLDD WIFTADAAGD RLLKHFETNS LKGFGVEHLK
AGITAAGAVL YYLDMTQHKQ IGHITALTRI EEERYVRLDK FTVRSLELIT AMNEGGKSLL
DVIDRTVSPM GSRLLRRWLL FPLKEAEAVR RRQDVTDYFF HQQETAEMLE RQIEQTGDLE
RIVSKIAVGR VSPREVVQLK IAIQALVPVK QACMDSNEPN LARIGERLSL CVPARDRIEK
ELNSDPPALL NKGGVIASGV NAELDELRAL AYSGKDYLLQ IQQRESGKTG IPSLKIAFNN
VFGYYIEVRN MHKDKVPPEW IRKQTLSGAE RYVTEELKEY EEKILGAEEK IIALENRLFN
ELTVGLAEYV QPLLTNAGLI GRLDCLLSFA KAARTHKYTR PDVDDSDVID IKAGRHPVIE
KQLPAGESYI ANDVYMDNER QQIIIVTGPN MAGKSALLRQ TALITLMAQA GSFVPAESAR
IGLVDKIFTR VGASDNISLG ESTFMTEMNE AAGILNNLSP RSLVLFDELG RGTSTYDGIS
IAWAIVEYIH EQPAARAKTL FATHYHELNE MERSFKRICN YNVSVKETAN KVVFLRKLVR
GGSEHSFGIH VARMAGMPKS IVKRSGEILK QLESDNRQDG IGKPIQGIAS AAEGFQLNFF
QLDDPVLGQV RDEIKNMDVN NLTPLDALNK LSEIKKIITG K
//
