ID A0A180FDF2_9BACT Unreviewed; 698 AA.
AC A0A180FDF2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=ATP-dependent DNA helicase RecG {ECO:0000256|ARBA:ARBA00017846, ECO:0000256|RuleBase:RU363016};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU363016};
GN Name=recG {ECO:0000256|RuleBase:RU363016,
GN ECO:0000313|EMBL:OAV68865.1};
GN ORFNames=Barb6XT_00777 {ECO:0000313|EMBL:OAV68865.1};
OS Bacteroidales bacterium Barb6XT.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales.
OX NCBI_TaxID=1633202 {ECO:0000313|EMBL:OAV68865.1, ECO:0000313|Proteomes:UP000078346};
RN [1] {ECO:0000313|EMBL:OAV68865.1, ECO:0000313|Proteomes:UP000078346}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Barb6XT {ECO:0000313|EMBL:OAV68865.1,
RC ECO:0000313|Proteomes:UP000078346};
RA Tai V., Carpenter K.J., Weber P.K., Nalepa C.A., Perlman S.J.,
RA Keeling P.J.;
RT "Genomic and NanoSIMS analyses of nitrogen-fixing bacterial ectosymbionts
RT of a protist inhabiting a wood-eating cockroach.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Critical role in recombination and DNA repair. Helps process
CC Holliday junction intermediates to mature products by catalyzing branch
CC migration. Has a DNA unwinding activity characteristic of a DNA
CC helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-
CC DNA). {ECO:0000256|RuleBase:RU363016}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363016};
CC -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC {ECO:0000256|ARBA:ARBA00007504, ECO:0000256|RuleBase:RU363016}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAV68865.1}.
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DR EMBL; LBCW01000036; OAV68865.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A180FDF2; -.
DR PATRIC; fig|1633202.3.peg.2440; -.
DR Proteomes; UP000078346; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR CDD; cd17992; DEXHc_RecG; 1.
DR CDD; cd04488; RecG_wedge_OBF; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR004609; ATP-dep_DNA_helicase_RecG.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR045562; RecG_dom3_C.
DR InterPro; IPR033454; RecG_wedge.
DR NCBIfam; TIGR00643; recG; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF19833; RecG_dom3_C; 1.
DR Pfam; PF17191; RecG_wedge; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363016};
KW DNA damage {ECO:0000256|RuleBase:RU363016};
KW DNA recombination {ECO:0000256|RuleBase:RU363016};
KW DNA repair {ECO:0000256|RuleBase:RU363016};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU363016};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363016};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363016};
KW Reference proteome {ECO:0000313|Proteomes:UP000078346}.
FT DOMAIN 283..445
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 464..624
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 698 AA; 79064 MW; EBAB47586481573F CRC64;
MLELDKRSVT YLPGVGSRKA AVLKKEADIA SYEDLLYYFP YKYIDRTHFY KVCEVNGDLP
YIQLKGRILQ FDTVGEGRSK RLVAKFSDGT GVIDLVWFKG LQYITDKYRP GIEYIIFGKP
TEFGRLINIP HPEIDAIEQS DQVTGGMVPF YNTTEAMKKA FIHSRAIQDM QYALLSSLNW
EMPETLPPHI LSRIGMISLP EAMRNIHFPQ STEMLQKARL RLKFDELFYI QLNILRTADL
RKRKLRGIVF PKVGHYFNTF YSKYLPFELT GAQKRVMHEI RADMGSGRQM NRLLQGDVGS
GKTLVALLAM LLAVDNNYQA CMMAPTEILA GQHLVTILGF LKDMDIKVAL LTGSTKKKER
NRILPAIATG EIQIVIGTHA LIEKTVAFAS LGLVIIDEQH RFGVEQRARL WTKDSTVPHV
LVMTATPIPR TLAMTLYGDL NVSVIDELPP GRKPIKTLHR YDNKKAELYG FLRKEINLGR
QAYIVYPLIE ESEKTDYKNL EENYALFKEV FPEFSVSMVH GRMKPAEKEE EMQKFVSGKS
QILMATTVIE VGVNVPNASV MVIESAERFG LSQLHQLRGR VGRGAEQSYC ILVTSYKLSN
ETRKRLEIMV NSSDGFEIAE ADLRLRGHGD LEGTRQSGEG LDLKIADLAA DGQILQYART
IAQEVLEEDP ELLSEANRTA AERLKALFSR KINFGMIS
//
