ID A0A180GCF3_PUCT1 Unreviewed; 1228 AA.
AC A0A180GCF3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=PTTG_28369 {ECO:0000313|EMBL:OAV90340.1};
OS Puccinia triticina (isolate 1-1 / race 1 (BBBD)) (Brown leaf rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX NCBI_TaxID=630390 {ECO:0000313|EMBL:OAV90340.1};
RN [1] {ECO:0000313|EMBL:OAV90340.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV90340.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAV90340.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV90340.1};
RA Cuomo C.A., Bakkeren G., Szabo L., Khalil H., Joly D., Goldberg J.,
RA Young S., Zeng Q., Fellers J.;
RT "Comparative analysis highlights variable genome content of wheat rusts and
RT divergence of the mating loci.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAV90340.1}.
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DR EMBL; ADAS02000104; OAV90340.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A180GCF3; -.
DR STRING; 630390.A0A180GCF3; -.
DR VEuPathDB; FungiDB:PTTG_28369; -.
DR OrthoDB; 1611579at2759; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR PANTHER; PTHR45786:SF82; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR45786; DNA BINDING PROTEIN-LIKE; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044}.
FT DOMAIN 352..449
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
FT DOMAIN 1164..1210
FT /note="DNA helicase Pif1-like 2B"
FT /evidence="ECO:0000259|Pfam:PF21530"
SQ SEQUENCE 1228 AA; 139030 MW; 30E60ADC7440620F CRC64;
MKVATSTHPD YESLISTIAE YSFPHYLGRC NNICNGCFAF HWNDESTLAD RKKQTKIYTM
CCQKNKVSLP SVDRSAQRYP SLIRGLLTDK NQRSLDFQQL TRMYNNTLLF TSLGANIDYS
VAGPMGVNVF KISGALTHRI SSIEPASDDP GFCQIYVVGN RGIKEAQFRI TQAQGRGGNT
GLAARMDPQI VLELMDLLTK INPYAQRFRS TIDVLQRANA KTFKLQGVPT PGADPKRYNC
PTIDEVAIVV QGNGDIISER QILLHRHDDG LKFISNLHSA YLPLRYPLFF PYGEQQWDNL
YRATTSRGKP RLDNRKVESL EWFSFMLFRR RKKFSPILAG RSLFQEILVD IPRCMQQLYQ
DAMALCRKFG PPSYFITMTA NPNLQEILDE TPLGEKSFDH PTVVARVFYL KMKELISQLV
KLERFGRVVA YVWTVEFQKR GLPHLHLMVT VDENDVPSLP EDIDNMISAE LPDPIKSPVL
HKLVCEFMLH GPCESRPCWN GNACRLGFPK AFSERTINVD GAYPVYLRRN DGRSITKQRS
TFDNGSVVPY SPYLTRMFEC HINVEVPVNT TAIKYLYKYI TKGHDRLSLA IDSNDEVQSF
IEGRYIGPCE AAWRLFKMPL SDRWPPVTRL SIHEEGEQLV YFKSQDGLEG QINNGKATQT
SLTGFMLLNF EDAIGADGRH ARDLFYEDVP TYFWWDKSRK IWVPRKTKDE CVGRIFLVSY
LAGERRVLLG LLVNDFLYNE ALSEAAVVRS GYQLAQMFAM ICVHSPPSDP LKLLNTHYLS
FTDDQPRIDM RQRYSKRLND AERKVMALFR LEDILAEMGS SLRSCGLNPT KKEARMLVGM
KYDDGEVEEL CVTSARLTKN KKKFNQRQKC FYLKVKNALH RRRRQLFYLD GPGGTGKTFA
LNTLIDLATV NEYNKIAVAS SGVAALLLKF GQTAHSAFKI PIDAAAGVEC PIDEDSFLAL
KLKDARLIIW DEVVTIHKNA IEAVNLTLKR ICGSTDDFGG KVVIFSGDFR QILPVVKYNE
YPPASFSTIK SSTLWDNISP FNLDLHRKKK NNIDFAASLL LLGEGKRQKS DYAVIKLRHI
NVASYKSRDE MRSALITFVY DDLVLVRSAK AATTYLNERC ILAPLNKDVK KLNDEVLSLL
PGDLVTLTSI DTPDPDSISS LPEECLNKLS FSGFPEHEIS IKLGMPLVII RNLSIGAGIR
NGSRIRVVDF GIGFIRGRLM SGPLAGTK
//
