ID A0A180GFI2_PUCT1 Unreviewed; 1255 AA.
AC A0A180GFI2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Signal transducer {ECO:0008006|Google:ProtNLM};
GN ORFNames=PTTG_05091 {ECO:0000313|EMBL:OAV91476.1};
OS Puccinia triticina (isolate 1-1 / race 1 (BBBD)) (Brown leaf rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX NCBI_TaxID=630390 {ECO:0000313|EMBL:OAV91476.1};
RN [1] {ECO:0000313|EMBL:OAV91476.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV91476.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAV91476.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV91476.1};
RA Cuomo C.A., Bakkeren G., Szabo L., Khalil H., Joly D., Goldberg J.,
RA Young S., Zeng Q., Fellers J.;
RT "Comparative analysis highlights variable genome content of wheat rusts and
RT divergence of the mating loci.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAV91476.1}.
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DR EMBL; ADAS02000080; OAV91476.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A180GFI2; -.
DR STRING; 630390.A0A180GFI2; -.
DR VEuPathDB; FungiDB:PTTG_05091; -.
DR OrthoDB; 5482027at2759; -.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09395; LIM2_Rga; 1.
DR CDD; cd00159; RhoGAP; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR23176:SF141; TRANSDUCER, PUTATIVE-RELATED; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00412; LIM; 2.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00132; LIM; 2.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW LIM domain {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 78..137
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 908..955
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 992..1181
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 137..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 762..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 557..626
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 698..746
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 157..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..225
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..900
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1255 AA; 137178 MW; FB092DA048F39B9F CRC64;
MENGQNEGSS SADRIICNGC KLTLEENGTA SDSVVVSFGN SLWHVDCFRC AKCRNLVEHD
TNLLLLSDGS PVCENCSYIC SVCKLPISNE AIVTGEESYH ADCFRCRSCS NRIEELIFAK
TSQGIYCMTC HNERVTRSRR HAEAKRNKST ANTTSSGTKK ERDRERADKP NPNRSKPRNL
IAPQKSPQPA NSSSFPLSAT DPALNSNHSN HHHHPHQHHH HHHLPGLPSS HPDPSNKPLS
SLPNTPRSPH PPLKTNSSSN SLLNSYLSHQ PGLASSHGSS TVPHKESYSL DHGQRPLQTS
RSTSPILPTR RRGGSASSVH HPSNNGHSAA LHPHEPINPH HHASSQAAQN TITRPSTADG
KGPSSKPLQS YFTSSAINRS YESSPHLPAN RSHPQAEHGR TAMDRNRPIA PRADPVDPKL
RTKHRSVSLS SFDDITLQNQ NNLLHPGPGS DTQHHMNLAS DPTAFSYNDI FSSLDHNPDG
QAEDPTRLMS QLELSAIDIE DLLATPTAVD PRDPRVSSTA GRPEIDEISK KVRESISLSR
DKPNQTATGL GFDVGLVEKL LWELDETKER MKALQDEYHQ MKRVSRSAYE GFSLARQNYD
TQVSQRQDAE AKMKELKTRM IEQASRLKEM DSLKTLEFQS EELKDSVSGL QKHVSQLAAE
RDFRIAEVEA LNDISDQVKK TGELPSGESL SERFDQLRKR YLHEVQDLAS ERDRLKEEVA
HLASIRESQA KELASLNQRQ DALTEMNATA VKRLEETRST ASRILARHPA PASTIKPSLN
SPTTMTGGQS SAHDSDFPIQ MSPEVNIATT RKFKWGKSHT HKGSTAASSR QLHHAKNASS
ISTPESAGIN NGAAHNDHPA NSSGTTNPPT NSSSGNLSSN NHANASAGNN NNSSSSNVAS
SSIVGLRPHN FQPVSALRPV RCDYCGDKLW GLAEVRCTAC GSYSHTKCAA NFFGCHASSG
PSNPSHGTMS SSLLVSGAGS IEEDVESVLF GNDLVNQARA ENKLVPSVVT KCIEAVEEQG
LNFEGIYRKT GGMSSVKMIQ NCFERGQSMN FNDLDKFNDI SAITSTLKNY FRQLPNPLFT
FELHEAFVTV ATMAQENIRL EALERVIYQL PAVHFETLKV LMNHLSKIEK QSEHNKMTSQ
NLGVIFGPTL LRSANPNRQF SDMPFTAKIV ELTVLNRPLL FRKPFGTNPS SSTPSPNSAS
PAAAPSLPAS STATMHPSLP RGDHHAIQHS SASSTPSSSN LSIIHPSSSS NLVAQ
//
