ID A0A182DWL1_ONCOC Unreviewed; 3010 AA.
AC A0A182DWL1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Tetraspanin {ECO:0000313|WBParaSite:nOo.2.0.1.t00026-RA};
GN ORFNames=NOO_LOCUS26 {ECO:0000313|EMBL:VDK61010.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t00026-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t00026-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK61010.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; UYRW01000002; VDK61010.1; -; Genomic_DNA.
DR STRING; 42157.A0A182DWL1; -.
DR WBParaSite; nOo.2.0.1.t00026-RA; nOo.2.0.1.t00026-RA; nOo.2.0.1.g00026.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF00058; Ldl_recept_b; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 10.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1031..1047
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1054..1077
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2748..2772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1559..1598
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 1695..1737
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1738..1783
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1784..1826
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 1882..1920
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 2206..2248
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 2562..2601
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DISULFID 2666..2681
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 3010 AA; 341969 MW; 4BCA2671771D2702 CRC64;
MNICIMDDNT NSHCVQICLL LYTVLFWLTG LALIFLSLLT LLDPRRNYIL DLVDFSEDDP
LLRGASYLAL VTGSITMIIG FIGCCGTIKK SLCLLITFVG DKLSVYLTKL AHDRYYRIYW
VTPLIDIIQY YFLTNDFDQK LQLLIRQSYG INPNIEYNAK VTSLIDKLQF NEQCCGSVDY
KEWSSSRWRT SFWTNVELLQ QQPQFGFDVV PVTCCVQLSG ATPMNPVARS SARCQQFQAN
KLWRHQTQQC CGATGPHNYY DSFWYKTNTE RGTISFVPQS CCKQVQEARA WLIKPIDPMC
TSYNYYTSAF NSSVNIQTSK VCLNTNYRPP KARYDTLKTM VNEEKGIETM ERLKIVISIL
MANTSASFFS QLRRASCGKV AMKEAFKKEE LCNELNSRLV IWTEARSLVE FSHILVGYSG
LSQKAVRLAN CPDSHICLDW FIICSISDLS MVKKGKKHHK KVKKVKSKDS AQTLLEEKGH
LRQEVSSDDL SSIRKRVETE TFSDLLWISS RIENISRAPG RILRNDEMCP ENAELKKRRI
IASEYHRKGD QKFLKQDYRG AYADFLHAMK ILGEHGNISN EFGRDMKLIR VYQDKCCICF
WMLYRIERNQ SHLTKCFECY NQLIEKDPTN AFWYKRRATL QRDEYLTILL DFALFAALMK
EYRIIMTKEE VKDTIYCYRE TAKAAWSLEK EKLETRKPFL TSDWINLWVL CPCDDVLLED
LLSVHEEDNN PENKSTLAES AYKDALKQTA RGCHSLAVNT LLDAYTHGQE MYRSEAFLLL
SLIYSQLHEN EVEYYLDTFI DFWEVDQFKV PVHRRKQIFM RYMSLARALL VSPLENLDLS
MFTPKEQAQF YTQTALTVAL RLQLLGGKDW MQKDVSNMTK LENIEKLCDR AIKADKQSLQ
SGMLREYTVM MISVIDNASS DSVRNALLTM TEYLEANQRH FEADHHYSFA SWCLFSAFFV
VECIDEAIKY GRVLEKYLFF PGFVSSFLIE KECRIKENID TENVLKCINK VEERLSNDPE
NFRLYLNIAE FYYHLLAFFN FCFSYVFEFT ALDIFLYITL LVLILYITTY PLFWRLFPQL
LFSICKKIFG IPHLLRNLPI FVSLCEFLQP LIRPPNDFIK EYHGRSKLIR KLSYKILASS
YLPRAVGTAV AEMEKHLQET SATNYIDSGV SDSISEIYGK EDPENDEPEE LRFLNRIYMI
LKNIIKRYGI TDDKEWVEAV IDIAMRSDRE ITAEEISDTL ANIAISEAAV LTKVPLLARQ
RKTITQLTLD IDKTMITSAT EIVSNIDESF PVLIALDVGK NILAYMESWL RSSSGNIRVI
ALGDNSTVSA YIHRSSGVAE ETVTSLAIDW VTSKLYIGVE TASIHNAGRI EVCPLDGQTS
CAIALYSSFE NQNSRVDALH SLVLDPVDGY MYWLNRVHKR IERAWMDGRH HDPHCFKDDT
TDVIATSALT LEQTSRMLYY VRTRTSLDDS QIWSCSLYDR ESCRAIVNKV NAFYLDVFSV
EIVKDHLIWT SVTNQNSGIT ICEKVDCDRT AREVVNSSGV EALIVSDKQV QPLRQSLNPC
GSKNGGCSHI CVLIPGVPWR SCLCPVGVRL LQDRLTCSPN GIERLLYVAT TSGLIFISLD
TTHHTPLLFP NAASEIRDTK VVHIDFDPVD KKLFMIDGDM GVIRRCNPDG TGMEIFIEDS
DKLVSDALAV DWLNRNLYWL DSNVAQIKMQ SLSSKGRQIV ISHGLKQPRG LALDPDGGYM
FFSDWHESTS RIEKAWLDGS HRRVLVSLEK DAWPNGIVVD ARHKRLYWTE GSRSFIKSVA
LDGKLDVQVF SESVNHPYSL TILGNSLYCN SLYGQKISVF RVPRHNESFF GVQLSAVSDS
VIFGQMGIRA VSLNRIPEGI SPCQTNNGGC SHICVKLPNG ERSCVCPVGY ELQVDRATCI
MPVAFLIYTQ SITVNSANSI MRISLGATPT NNHRINIADM TSAPVSISID QNSQRIFWSL
EGRSRSIRSL LRSAFFNGSG LETVYEGNAV NYIAVDWITS NIYWCNMEQR RIEMIRGDGR
RHRTIAWENI DPRYLVIHPL QRFLVFVNYY NRQKITINKM PLHGEQSGGE VIVQQLNTVN
ALAIDFDSEL LVWSELDERG GGVSVSDFNG QEIKSFAGRR RVRLVYSKQL LPAALTVYNR
QIYIANMNNN TIDLYNGDTL TVLHNDISHV TNLAVAHSQI SKGWNGCVQN NGGCSDICVA
VGESLYNASA KCFCEDHYTF DPVGGECLPP KHFLLVAIRG RFIRFNLRQA VTGDIFWKDD
PYSILSVTNV GTPVSVGVDL FSSNRSIYWI DSNDDRIIKR SSDLFHSTTQ TISLSRLSNC
AILFHLAVDE VGRQLFVSCA EHGLSHASSI HVWRIKSNDH LEYIGVIVSG RERSSVTNRS
PYPRQIALFP RLNLLFYVDG GGSIPVIVRC SLNGRQCVQW EAQNLTHIVK LHAYEINDRL
YYTTTNGLWS RDAHVFSDVR HHIKARPSDI DMVPINEKKL IIIAKNESQY NDLLLELMDD
VPAVSLDKLK WSTSSPVSLK RILALTVVGN IERDFYVNLN HTCAVSHCSH LCRVPRVSRK
RHECLCPLGF GLQAPSETFC FKHASCLHWQ FKCDDGQECI HAMAKCDGRH DCTDGSDESS
HWCDNVAFDK WPCHNREASI ARTLICNGVE DCADGSDEVH CRCTNPLFYF DCSFGPNAVL
HPAECISREL ICNGISNCYA GQDEEKQLCA EFGVMITVAP ILLPSFEWII PLAVFFFALS
IIMSVCCCHF SMQRSPGYNS VRAPTIHSLP MNAEARVLLP AHPDGTQIEF QLRTYSVGVS
SSLYNALPPP NSQFSTDAIS YRRSLDGNSS ERSSMIAAIS AVVTKANSRK FFAPPPSAAS
LSTYGVVKPA GMRVHMQHDG TDFMRNKRKQ RHRARTDSTR IRSLPPSCSK IILIDPGVEC
SDDESQQPRV PTNSRIVSSI DSSSMESTRH ILLPSSHFIS SIEFAQQQHL FDYSSTSSDV
SLSLAKNQVS
//