ID A0A182DWQ0_ONCOC Unreviewed; 1109 AA.
AC A0A182DWQ0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=PNPLA domain-containing protein {ECO:0000313|WBParaSite:nOo.2.0.1.t00068-RA};
GN ORFNames=NOO_LOCUS68 {ECO:0000313|EMBL:VDK61132.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t00068-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t00068-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK61132.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; UYRW01000005; VDK61132.1; -; Genomic_DNA.
DR STRING; 42157.A0A182DWQ0; -.
DR WBParaSite; nOo.2.0.1.t00068-RA; nOo.2.0.1.t00068-RA; nOo.2.0.1.g00068.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd07204; Pat_PNPLA_like; 1.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR002641; PNPLA_dom.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF177; CULLIN-2; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF01734; Patatin; 1.
DR SMART; SM00182; CULLIN; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087}.
FT DOMAIN 21..188
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT DOMAIN 949..1083
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 1109 AA; 125888 MW; C8E69401778E839A CRC64;
MPASGVRIIN ADPERIYKAS LSLSGCGFLC IYHAGVCAAV KKYAPQLLQN RISGASAGSI
IAAAIACNIC ISQATSLFLS VVSEARSYTF GALNRDFDLL KLVRTKLNDL LPSNAHEICT
SRLRISVTRF HDMGNVILDE FHTKDELLDA ICCSCFIPVY GGFVYPTFQG EIYIDGGASD
NQPVIDTNTI TVSPFSGESD ICPTDEESAS LFEWNFGGTS IRLTANNLYR AAVCLFPPST
EECAAMCRSG FNDALKFLVS NGFMSNAVCL STEADLLISL NHINKGVGAI LTSDSAVYQE
SHKDEKIVEY IDAVLATDST QLSHSVQNVF DKAMKKNRFL DYIYSFRVMQ LAHYMTLPLT
AAYQWFKFCQ CLSAWLTARI TRRIVDDWQS MRVKHIIDFI LNEIHLQGTK VSARFSQQLT
ITEIEFSGID QRSFVQEQLN INLSSEAIKE REVLRSIDRL LSKKSVKRDC ITTLPVKKKS
TLFNNILHTN EQNVIEGDKT SSQIIEQTTE LQHRSDILVK VEEKQVMDIV TPKSDGGLQM
AQYQCSFYSL RPKQVDFDAT WKSIENSIKR IMKLQPLERR IWDYNFYDIY SLCVAIPKPL
SERLYRKTEE CLEGHVTELY QLINSTNDSE LLSIYCQLWN VYYKGALCVH NLFGYLNKQY
IKIKRCTEIE GGYGTYSQYL TQKDIKEIGL LAMEIWRKKL IDPMEKRLVG HVLSAIAADR
EGRNIVPVDT VRGAIMSFVQ VDDVDGMREV LDKSPSNLPQ NYETYREKFE KKFLQTTTEY
YTVLSIKLLS ELSCSQYMES VIARIEEENE RSIRFLHKSS HEKVTKLCQD VMVDAHKERL
YAVCHEYIEG ECMNDLHNMY RILKPINGGL LVVIREFQNF VKKTGLEALK GMRGDNIPQQ
FVENVLQVYN RFSSMVAKVY YDDGDFVGAL DKALQAVVNY REDPRQAPKA SERLARYTDT
LLRKSGKGLS DSELDTKLSQ AIIIFRYIED KDIFQKFYSK MLANRLITSA SLSKDAEESM
ISKLKQACGF EFTSKLSRMF TDVGLSHELT DKFISHCAAS NITLNVQMTV LILQAGAWPL
SAPNSTPVSG QINFKNYYVV LENLEYSQI
//
