ID A0A182DWX3_ONCOC Unreviewed; 1767 AA.
AC A0A182DWX3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=RRM domain-containing protein {ECO:0000313|WBParaSite:nOo.2.0.1.t00142-RA};
GN ORFNames=NOO_LOCUS142 {ECO:0000313|EMBL:VDK61470.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t00142-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t00142-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK61470.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; UYRW01000012; VDK61470.1; -; Genomic_DNA.
DR STRING; 42157.A0A182DWX3; -.
DR WBParaSite; nOo.2.0.1.t00142-RA; nOo.2.0.1.t00142-RA; nOo.2.0.1.g00142.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19169; SET_SETD1; 1.
DR CDD; cd22541; SP5_N; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR024657; COMPASS_Set1_N-SET.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR044570; Set1-like.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR037841; SET_SETD1A/B.
DR PANTHER; PTHR45814; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR PANTHER; PTHR45814:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR Pfam; PF11764; N-SET; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01291; N-SET; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 105..176
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 1628..1745
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1751..1767
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..544
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..621
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..681
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..848
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1239..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1273..1293
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1767 AA; 199783 MW; 9D8738C001822462 CRC64;
MDAHEGASSH RNGGKVSVGG SNRSRPASET VHHFHHKLAW KAINIDAKHV IFRCDGICKD
NPKYNVHTLG DPRNPLTRFR NVESIDLPLP SFVLDNNSVG PQPKREVSIF GLNDNINHAF
LSNMCQKTGQ IIEVFVYMHP RTKKHLGMAY VVFQDVGKAQ SFVTKNNGTS VMGQTITCII
DPYAKEISRL YEKQAMEAAP VPRYLSRLDH NRLTEFRKIN SPSISEHKNI YTSPSPSTSG
QQSTDFKILE PAPQKQPDES ETAFHHDKGR QIHQQSVDAT LTKTAHIENV VPPNERSTIP
SITEHFPLST VSSSSTNLSY PSLATHQTFC SHHLMSHQHS QAPFTYYHSM PSNPISPLPS
FPPISSSVST FSPLPPLPPI TGRMPFPIWS NVPPPPLRTS VPNIWPRAKT IVSASVPSQV
LSIKSSVPTI SNFASTAYQP VPSTSSFEET APMDPAPSKE NKEKKKLKTI IPGEQKRKRS
IPASGKVKVR KRKRLREFVS VSSASESSNS KSDERSELSE ESSQSSSSTV KRKLRHRKKG
IVEERKYYKK KGAGGTSNYY REIVIRKNDN IRKCSHETKS DLLQSPELVE EVESYQRIRK
YKKQEQETTK RDEHFVEPDV DLPDLESVSS EEDQFSAQGQ ELKVQSAAKK SKSHSKILSM
KHTRQQQSRH VNWRKKRIME KRHKQCDNGS YGDRESSSLS GNEKGHRWSS SSSTVESEME
SDEPSSFGNN KRYGIDFSGR TGNKKLVDPY VGTCKHPSNL HSLKNLQMVN LSDIVEAVTA
SSEESDDEAV GTSDIVHQPI AHVKNNLTKN ESTQSLPTPT LITSPEKPSG DSPLPCVLQS
TPPTESSRSS FERRLENLFR STSMQPPIIE IHEEERSNDA GSISLPFISV LDVPFLPSTT
ATSAVVRQEM PLSEASFAER SNAEITVVKH PFDLNSTESW TNSQAQIEAN SICRNTTSDP
IGASSPVNAV NKVREENKHL STIMEEQSEL TEDKEVEIGD GLKENKKRKE LEEQILEKKR
AARENYVHAV YVAVREELKT VLLKDLMRKI EIVAFEKLEK GWKEKEKAKV EEQDDDFWQN
EAKDGVTDTP IPTIDKASVL SVKQTVSSKD SLNEMVRQVT EQTRAEMSAA FGPDTAALLG
TGLFFKGLGI ARNMPSFKKP KCDYFQKQVH LSPKRKQRSR SRNSYKSFCS ASSSTKSGRT
TESSRSYRRS ENQNRSRSES SLAEERSSDE DTKSENERSI SGSESICSTD LSSQVLSIRK
HDGSGIVTPT DGSMSEEDED EEEEVDKEEE EQQEEQEHIG KDFNEIRAIG IEEKAMLFVK
AEIGENNGCD ETESLSSSTA ASHLIEQNKI TEELRTRNKK VHDTANIEGY FNDHCYLPVE
LSEQLKKEFE ESISACSDSE TISAEFSETI KSEKSEKTLL QHVQDKTVKV KKRCYRNELA
SLLPPPVDVE QLTWETAWKP AKQWDKRTHK EEEEIFWKFE KEGLDAEDLM FLEKAFHEMQ
NDGTATWNRK LYWVPPRKVP EIHLLDKPKK IGKNIYYYDD PELEGVIPHS SGCARTEGYY
KLSHKEKRGV LRRPDVFLTE INEKDDEKAR YMMQSTREAR SMNRRLLTSM GDTSSDIFKV
NQLKFRKKLI KFARSRIHGW GLYALEAIVP DEMIVEYIGQ KIRPTVADER EKRYERRGMG
SSYLFRIDSD NVIDATQMGN LARFINHSCQ PNCYAKIVVV DGEKRIVIYS KLPINKGDEI
TYDYKFPIEE DKIDCLCGAP GCRGSLN
//
