ID A0A182DX66_ONCOC Unreviewed; 3042 AA.
AC A0A182DX66;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Vitellogenin domain-containing protein {ECO:0000313|WBParaSite:nOo.2.0.1.t00238-RA};
GN ORFNames=NOO_LOCUS238 {ECO:0000313|EMBL:VDK61688.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t00238-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t00238-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK61688.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00557}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYRW01000021; VDK61688.1; -; Genomic_DNA.
DR STRING; 42157.A0A182DX66; -.
DR WBParaSite; nOo.2.0.1.t00238-RA; nOo.2.0.1.t00238-RA; nOo.2.0.1.g00238.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR Gene3D; 2.20.80.10; Lipovitellin-phosvitin complex, chain A, domain 4; 1.
DR Gene3D; 2.20.50.20; Lipovitellin. Chain A, domain 3; 1.
DR Gene3D; 1.25.10.20; Vitellinogen, superhelical; 1.
DR InterPro; IPR015819; Lipid_transp_b-sht_shell.
DR InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR InterPro; IPR015816; Vitellinogen_b-sht_N.
DR InterPro; IPR015255; Vitellinogen_open_b-sht.
DR InterPro; IPR015817; Vitellinogen_open_b-sht_sub1.
DR InterPro; IPR001747; Vitellogenin_N.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR23345:SF38; VITELLOGENIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23345; VITELLOGENIN-RELATED; 1.
DR Pfam; PF09172; Vit_open_b-sht; 1.
DR Pfam; PF01347; Vitellogenin_N; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM01169; DUF1943; 1.
DR SMART; SM00638; LPD_N; 1.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF48431; Lipovitellin-phosvitin complex, superhelical domain; 1.
DR PROSITE; PS51211; VITELLOGENIN; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Storage protein {ECO:0000256|ARBA:ARBA00022761}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..3042
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041046729"
FT DOMAIN 40..623
FT /note="Vitellogenin"
FT /evidence="ECO:0000259|PROSITE:PS51211"
FT DOMAIN 2514..2686
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT COILED 2275..2365
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3042 AA; 346536 MW; 905F4FAA2429DE7F CRC64;
MHLEWLLPLQ AIITWTVAYD GTSKDVCAIA CTGVSSDVKY DVGRSYVFDV TSRTILKMGQ
ERDTDVIQNA QAHISVHSSC EFSLKLTRTS LRGMDVGNEW SHILERSPLR FAFDDGEVKA
VCPHDGDPTW AVNIKRAILS AFQTKLEGAR ETDIYGDCPV TIEKRKSNEV LNLKTAKQLN
ACYREHDIAG VRAVPYRLES KIQIAPMMET KQTCERQITS YNLQQVTCTE DYRVASPFGE
GNLGTLHVEQ TLRAVGISTA APQELFKERS SIVFDHINDH LHPKSSPQFA RQIIDKLCRP
DDRVDPDAAS HFADLVHNLR GLSETEISSI ANLQCDAFID ALAACASHAC LLQLGNLINS
GAASESVYSS LALLPNPKKG TMDSVAAFIE RVPLHGLLAV SSLVQSYCIA HPTCGMEPTV
QRIIHSILSK LPPGCQVVHQ FEEIKEAVII LKSIGNIGHE EHSLSSLIDC IANDRIPKVV
KIAAIDALRR KPCSQQRNSK ITELFLDEKE NAEVRIKSFR QLMECVNDEI LQIIVDQLHN
ETINQVGSYV RSYLNTKQRS TNPGSRNLQY LLKRFHIPQR FKLDSNRFSG FYELGYLDRE
NNYGGHMDTS ILLAPNGYIP REVAFNFTVH LFGKSINILE IGARTENMEE AEEELFGPDG
YISNPNGHVF REKRFQSRYP KLNHLKELYR RRNIGVENQI RASFYMRMFG DDLQYCGFQR
DHQRFLEEVK ESIELDKVLT KLMQEKTKKL SYYMLPFELS QTLPTLSGLS LQFLVNISVA
AKIDGKLRLN LVNLLQRKGD ANSQLELHPS VSIARGGVIL LRAGHVASGV MTMSSLHAAT
SVVQSMEMTD GRKLSLKIDV PHQHLLLAKI RTDITKIESN HHQPFTVGRH IHEIAKKHYC
SGDTLTKILG IQACVDFHAN LPIMEGNIKV EKVDRGLNSY QFLVERASTR GEQKLLISMD
TPGSEINRKM EATEAGERNS YKLNAKSVAE SVTAAEVAAE LQYSISKPYA MLDFHLDKVF
SKPIILKTLI NPETPKYEGK LEYSGPDFNG KLDTSVICQG MFDLKGTISS EYQIVNNPKH
ALEIGFEQAF QKSGTNHNFK HVLHATGTTF NKFNFQVLSD RTGNNMNNLL EVTYFGEQLL
ANLDVTRGPN NIYIAVGRMK CDRLGIDSKA DITYQNRFPL QFMLKINAES PRIQNIHASA
EYVVKVDPKW NFNGNVLLRY PGREIALNKK IDELTNGQYK TETHLRWDPN GRIDVVSDVV
CRPRENEYTI ESTASIAGVS EPISIKKHIK YQSDNYNLQW EAKQGGQMIY ELIANLVGQF
GDQQQLNIKI NSEKFEPRIN YRLTAELQPS ADSITALATV HKDGRHFGAG NIIVPKKFDL
PNQQYRGEFS WIYQNRPRKV VVEYNLTKHT YDSLHAMKVQ SDDNLDLNMQ FDRHQDRMTL
KCDLDKDRIR TVSMLLTATP FHWDFFEVDG HLNTDRPLQQ RSIKAKAGFL YRIDQANMQG
LLEVNNERYG IEGHWRKVLQ DIGRHYIYAG KFEIPQNRIS LEQQLEVLDT MTIRKAKTIF
ELISAERTYN LTNEIKSDDT SFHTATDLIG SGIMLKHTVG YNREHGQRTL KKHLKYNEKE
INIDTVTVYR DGEVKVDIGA SSTFDMIRYG KVMFNCRKGQ TFWNCDAESN INNQYVIKGH
ETLSPQNTDI GYLIKLGNVQ VSKYNANAML RRAEILYNLE MDVNGDRGIV KLQTPTHAID
NPQVRITRKG PSEFEVHTES GSRGRIYAHV KTGDYDKLLK IQITEIPEPF ELHLENSLTD
GKQKSIAELT LDPLGQKRTY GIENEIEGEG ERFRALRSIL KRPKRTIKIE LLRPARNKYV
LSLLPNVGGR RLPTVAEMTY QKTTDGYHWE GSISDQALKT PLKAKVVYRK DERDKFNYRL
DWQTEFAYSD EPDKLFSNSL HLHRSVVPST RRKRTAIRRG ERDDNVRFVV ELKSIHLASN
LNTRLWTKVD RSLIGENAIP VHATFGLETR NLQRQPVEYS LEMRTDAVKF TEIQLKSPNS
VLKARIDKTN DNHYRVGFYE NNERPYIVGE LNLDDNGPVF EYRDERSQEV KLHASAQKLN
DYEGKIDVWH SEASKKIQDA LISLQMKEGN VWNSKIYIRP AVESEIMKKS KETVSKTSEL
QQCSFMRDAF LPIFSSHKQI ANDVATTLDR VIKEWTEEHR SFAAELGSEY ASLVDEIENN
YEVIKEAILA AYDHAYQEME QFVIIQAVSN SDFTYRLLQL MDGGSGIQQE IMTALRPISD
LIDQLNKELS DLQRNAAIVV DRLEDTLKLN DLRRALEEYK QNFEQTDVIQ IILYEMRKLS
HQYQLPDLER TIADMEVNRR RYEGEALEIY NKIKNFLLDR VIVSMLSKTT SAIFDSLDDN
QIRQKWQEII NYLRGKITGN ELAKQFWRNY IPTYKRLSPG KYELEVTVPY SVSSLKEVLS
NLHPQRFSAL KSSIIESLGL SLKDQEFAQS LSDTIYTYKS TKFDPWKMMS PFKSTAYIIN
GDRFVTFDGR VFAFHARCEY LLASDLRTQR FALFAIFSSK GHLEAIKAEL RGEEVILYKS
GNVQVNGAPV SMPWQKIDGI DGAVLISVCR KDHWTALQTY EGLCVRCNSQ FDICEIVLPG
RMYGRSNGLL GLNDNEPSND RDLVDGTPND QLNVLAEHWA INGECRINQA RDLTHRDDDR
CQEYFQSSDS PLKLCFNRIR PKPFEEICSN GGKQQHCTAT SAYLQVCLNA GIMIALPHEC
VRCEGDLHLD DERKVENPGA EHDVVFVVEE RKCMDLHKDK IARIAQRISQ EQRSVRFGWV
GFGGEGVHHE PLVHYEQNEA LLDVSTFMRQ TQQSFEPVSG IEVPHGCPKK AVEFAVKHFP
FRFASAKSIV LVMCRKCSYR GHAEMLDMLL EQDITMHLLT LSKFKTSDGR KVVGMDAKQL
LDESGAQIGE RTSLLHPHDT CSVVAQQTFG TVFSLKHGSM VAASRITPKS KSYCFNCQCT
ANGLFARSIC RPCEMIEPAE LASYKVIDSE PDNDLQLLDV FI
//
