ID A0A182DXY6_ONCOC Unreviewed; 1221 AA.
AC A0A182DXY6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN ORFNames=NOO_LOCUS522 {ECO:0000313|EMBL:VDK62308.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t00522-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t00522-RA}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t00522-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK62308.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; UYRW01000051; VDK62308.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182DXY6; -.
DR STRING; 42157.A0A182DXY6; -.
DR WBParaSite; nOo.2.0.1.t00522-RA; nOo.2.0.1.t00522-RA; nOo.2.0.1.g00522.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0000003; P:reproduction; IEA:UniProt.
DR CDD; cd00064; FU; 3.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24416:SF600; PDGF-AND VEGF-RECEPTOR RELATED, ISOFORM J; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 6.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 711..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 779..1047
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 814
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1221 AA; 139083 MW; BE00A3CC77D945F4 CRC64;
MITLRNLEII WGDKQHDDVV ALHISNNMNL KYVNLPKLRS VQRGQIVLMH NPYLCNWNTT
VSYDELLGKP SESRVQLIDN FEECLGDIHT KCSTVCGKHC WGPIKGMCQI VYREICPEEC
PSQMCYQSKN ETHCCDEECA GGCFGEGKSA CIACAKLEQD SKCVDKCNGL TDYDWTLKMT
VPHPDPRYTY DRYCVKQCPE ETLIQGEYCV IHCAESYWHD PERNTRICEK CEHDICPKTC
YLDEPIDSSN IGDLENCTLI EGFVEILRHP FEPHRKFFSD GRPPIDIEKL TVQMLKALSK
VKIVTEYVNV QAADYSPESL NFLRSLRTIE GRKLPDQIAL LVTSNHNLKQ LGLRSLKKIK
NGRVYIGNNP KLCYLDTIND YWKEIMQGNV TTDLKIISNQ LPNVCENVGK ICDETCDENY
GCWGEGPTMC VKCADYEMDD KCSSFCPSEG YYVEGKKCQK CQSQCKTCNG PTTLNCTECL
NIRMQQGNNW ECLAKCPTTH YLHKNTCLPC SPACYNFGCT GPNAVAGKDG CNKCKYAKRF
DHGKQLMCLH TTGKPKDVCR DNNLTRYYAT ASSNEMLVVE FECNECSEEC LSCSGYGTSV
NRHKCKCAHY LTKTTSGNEY CTMKCEMNSF MIRPKSLDTI GECERCHELC DPSMGCIGRT
TANCTRCAKA GVLLENQLVC LEQCPINHPF IANDKICHTL DPEEQASKRR MYIIIISALC
AAIFIVALVG ITVKYIKYKK RYKEELEMNL PSIPEYEPMD PSMRPNMTRL CIITSENLEK
TQQSLGQGAF GTVFLGYWWP KGKDDGEKLA VAIKVVNDGS STAAHQEMLQ EAGIMACMRH
EHLLRLVGVC LSNGMQIVTP MRPLGSLKNY LKKHRQKLGA RDLLLYCYQI ASAMEYLYKN
RLVHRDLAAR NVLVKRTNHV EVTDFGLAKL LEKGKSEVVV GGKVAVKWLA LESLEKQIYT
HYTDVWAFGV TCWEVLTFGQ TPFQSVPPDQ IRKHLATGNR LEQPNNCTQE VYQTFLQCWL
RNPESRPSFV ILKEKFNQYC KAPHLYVLDR HYKQQFESVL LENQHELTDE MMYNNELPDQ
FKFSGITTTT TSTSVPPSPT TPCWVTFQQG DINMRQERRL GSTDSGRYQS DPVCDGRTEL
SMDEGNYLVP NNKLILYTPV VVRENGETEL MESAEYYNDK LGTDYYNQLR SLSQETKEKA
KSIKIATYQN DYYFAETETS L
//
