ID A0A182DZ18_ONCOC Unreviewed; 728 AA.
AC A0A182DZ18;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 13-SEP-2023, entry version 28.
DE SubName: Full=SEC7 domain-containing protein {ECO:0000313|WBParaSite:nOo.2.0.1.t00924-RA};
GN ORFNames=NOO_LOCUS924 {ECO:0000313|EMBL:VDK63115.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t00924-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t00924-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK63115.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYRW01000103; VDK63115.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182DZ18; -.
DR STRING; 42157.A0A182DZ18; -.
DR WBParaSite; nOo.2.0.1.t00924-RA; nOo.2.0.1.t00924-RA; nOo.2.0.1.g00924.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663:SF342; FI21420P1; 1.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000271087}.
FT DOMAIN 221..409
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 557..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 728 AA; 82526 MW; 31430D135BFFFE74 CRC64;
MLSEWRGPTI SVRALTSYEI SDELCRRQLQ VLERRYGGRL RAHTAATRIQ RAFRQSCLLK
QWKHLVLPIQ NSAVCSRNVG GQEHKDVLKR NTSLTDVPSA QACLHRPSVA PVRPKNCSPR
INLSVPERGC KVPLAIGENI GNAKFDNNLP HRSAVECLSP RLSQRRIVTD VVHPATHVWL
PRSSAITGRS NHSNSLPRLD KHATPCQPVS TSSNSHGVLD QRRRRQYRIA LNFFNKKPTR
GVQYLIEWGF VADNSLAIAN LLLHRRGLSK QMIGEYIGHL HNPFQSSVLN HFVDQIDLHG
MEVDIALRHT LSFFRLPGEA QKIERIMQVF SAHYSTCNPD KVALFHSADT IFILAFAIVM
LNTDLHSPSI KPSLKMKVGD FINNLRGIDA GYDIDRALLV RIYRRIRDSP FSTGSDHVSQ
VLVVDQSIVG KDKPNLVEPH RRLVCYCRLN QIIDRNKRQP ANAHQREIAK MASKRKSCCQ
YVLRTWMMLL GVRVSMFETP FYDYGIMITL PDGQEIYLNS KNDDDRHRFV ADVKESVAEC
AEMEAIRIDA ELDKHSLISR SDGPRERDSG LSEMEGNTSN SVVNTSSPNT PQQALNLCSI
RRLSFNSFDS GVIEESCESF SHSGCTYEAM KGTDNRTKLC QLDKLIIKAK QNLSPVAAQV
KLSITQTDKH EQSELERKAR EEILKDTALG VRRYEKIGPQ GWKKPACLRT NKKFLERILR
STQPKSNK
//
