ID   A0A182E0H1_ONCOC        Unreviewed;      1384 AA.
AC   A0A182E0H1;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=A2M domain-containing protein {ECO:0000313|WBParaSite:nOo.2.0.1.t01449-RA};
GN   ORFNames=NOO_LOCUS1449 {ECO:0000313|EMBL:VDK64205.1};
OS   Onchocerca ochengi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t01449-RA};
RN   [1] {ECO:0000313|Proteomes:UP000077448}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22919073; DOI=10.1101/gr.138420.112;
RA   Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA   Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA   Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT   "Analysis of gene expression from the Wolbachia genome of a filarial
RT   nematode supports both metabolic and defensive roles within the
RT   symbiosis.";
RL   Genome Res. 22:2467-2477(2012).
RN   [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t01449-RA}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:VDK64205.1, ECO:0000313|Proteomes:UP000271087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYRW01000184; VDK64205.1; -; Genomic_DNA.
DR   STRING; 42157.A0A182E0H1; -.
DR   WBParaSite; nOo.2.0.1.t01449-RA; nOo.2.0.1.t01449-RA; nOo.2.0.1.g01449.
DR   Proteomes; UP000077448; Unassembled WGS sequence.
DR   Proteomes; UP000271087; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.40.50.120; -; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   PANTHER; PTHR11412:SF179; LD23292P; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   SMART; SM01360; A2M; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000271087}.
FT   DOMAIN          454..544
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   1384 AA;  157623 MW;  72F717759C31C903 CRC64;
     MHYKINSSHW SEHVNITQCG RNATAPSTNL VKLTAEVLDQ GTGSRVKNNV EIDNNLAGFE
     LIPLRPGYYR DSSNISVWIK SMDGSSMRSQ EVKVDVRCIS TDKKQTLNLT SYEGRIGFLL
     NIPFSSSLYE HSCRVMLVQA RRKIGERLSR PVTLLLPSVD HFEWLQYGWI QQSPHNSVAY
     RVGEKFRASV PLHLATKLNY LVVCQDETIA EAGRVRDDGE IIFEITDVMV PYCALYVFGA
     NRTVQIDMIL FFVELSCKNS LTVSKISVGI RDNLTITISG GSNGLSLLSA VDIRMLDFMQ
     KYSSPLISKY WDLSMAERSL RTIFLDLIDS RNLNNGIGET CEEAGVLMLQ HLKQCPNFME
     SSSVISNLCL HSFILACEHL TGQTTTSKVC DRKTGHGCGM DGDLGTLKLA SAHFHFKSAD
     SRPHNRTSFE DSVSALLRRK TDLSSVIRQY FPEVWLFEDY NLGTSGRLNL TVRVPDTVTQ
     WSLQSSVWTP GDLAICQSSP SIITTQQKFF ITIDLPQHVY INESVVARVS VFAEQIERDM
     MLSICMTNLD RHVCGDVGAY GERGQPAYTR IHLTTTIPTS VRIFPLKFFR IGETEIMFIL
     KEEISYPGRY HCDIGEIYDA VKLKVIVAKR AETAENFKRM VLNPRKPMNL LTRSVNMHHL
     MMANETKNGN KNIIDYNEYR SEWEPQKLFT NISINLPDTE SIYSIIIDLS QFLSDGVITE
     SIMQNEIVLQ SNYRWKRSLS GYESFLTDII SSFAPALYQL KSLNSLDKKD FRKSESLNDA
     IGSLDLANIE SFSLTVLSTS LFCEADVDER IVCPLLTYLL KEITEDMDIR LPMDYFLDLM
     DLTATEDKHW FVKALVNQLA SDCIAYHCVR NDRVWISLRK SFFNLSDRTV LDIRTVAALA
     FMAPRSVSST MRIKLYSIAK DSMFPYWTTG RISSSDSLLT KFRTGFADHM NHRIVMSGDL
     FVNSLGLLAF VSRKIDPMLS LIELDLLADW IYEQLNENGQ TPSALDVYFA NRAIYEYRLY
     KINRNDGNHN RVTILCKKCK LIVHNVTVTP TVFNLPTTVR NITLITEGDG KVRARIRVLT
     TKKMRLRRGL EQSDLYPTKV TVVQNLVSPG IIQQEVCLKI LTSLIESLEV THGLFTGFTS
     RNSLFRILEN TTIHGVRLLD GVTISNHALK PKIPLCYELK ITEPRSAYEP DQLAPVAIIV
     RHPLYDIAGQ ELVAYTERFK RSLLQETIDM VCWDGSCSCA ETSCTVRCSQ CRSITKKHLQ
     HEICSENMFA ATVEVESYRS ENLNDSGYFI IEVSIKHWKQ NNMNMKTVLQ KPDRIEIWLR
     TCNIRCEEPE IGKVYYFSGN INGIVMDFNT RMHYVLRDDD RWESAREECG HLFSYLITSQ
     PCPL
//