ID A0A182E2G9_ONCOC Unreviewed; 683 AA.
AC A0A182E2G9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN ORFNames=NOO_LOCUS2169 {ECO:0000313|EMBL:VDK65704.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t02169-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t02169-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK65704.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYRW01000319; VDK65704.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182E2G9; -.
DR STRING; 42157.A0A182E2G9; -.
DR WBParaSite; nOo.2.0.1.t02169-RA; nOo.2.0.1.t02169-RA; nOo.2.0.1.g02169.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 100..266
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
FT REGION 448..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..469
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 77070 MW; A997D367475EE6BB CRC64;
MKTFWLDNLQ HTIQVRVFRR QHGACAKLTF CAYINSSHYA CSLSLPSFTV TLLQGSAVDA
DGVDMKHWYR FLLFVASLKI ICGERLSDQI YLDLSGGRYS CFRLLNGSHE IGCGSAEEGN
EGVIVYADSA DQLINLITSL DFSDRIITAF DIFLLNERII RVLKDDRVRG VLLLFNDSAV
TDGFSEDAFC PNKQFDLNGE CENRWNERGA LLPEGFRFIN WKKPIFVIEN RTEIDIIRSF
CYEAFNKRNL RGPVLCSARM KHFMRAAGNA EICLRRQRLF YGFSDSSISL CDPLGDKNLF
ATVPAFIKEF RPKILMLSAR MDSFSSFTEA AVGEVSVLTS LISLLAVAKT ISNHSSEFEA
VARHNRRAVI FAFFHGESLG YIGSSATVND IIKGEFPLDI RLKDIDSFIE VQQLDGSESV
FSAHIDSKSY DNPENKRKVQ ILLDAARSSL KQSESRNDGN RRDSKINVER KIQLPPSSYQ
SFLKEKRDIA GFVLRPFGRQ YIYNRINSLE DQNVFKNGTA KLKNQIIAAA NAVMGAVTGF
FTGGNKTETD LFSQYDIDEL YVAVLLDCFL KYPDWHSCNF FKSISKGENQ FEHYSKETYV
SVGRNNYSLI RILMTMLIVN VLGSKNAVNV PDREHVPFIM HGEFGFSVPQ GLCIIFFFTA
SYKSLSTSAS GISAHITSSI RLK
//
