ID A0A182E367_ONCOC Unreviewed; 525 AA.
AC A0A182E367;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Divalent cation transporter {ECO:0000313|WBParaSite:nOo.2.0.1.t02421-RA};
GN ORFNames=NOO_LOCUS2421 {ECO:0000313|EMBL:VDK66270.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t02421-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t02421-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK66270.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC {ECO:0000256|ARBA:ARBA00009749}.
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DR EMBL; UYRW01000380; VDK66270.1; -; Genomic_DNA.
DR WBParaSite; nOo.2.0.1.t02421-RA; nOo.2.0.1.t02421-RA; nOo.2.0.1.g02421.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 3.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045349; SLC41A1-3.
DR PANTHER; PTHR16228; DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41; 1.
DR PANTHER; PTHR16228:SF21; PROTEIN CBG01705; 1.
DR Pfam; PF01769; MgtE; 2.
DR SUPFAM; SSF161093; MgtE membrane domain-like; 3.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 64..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 100..232
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
FT DOMAIN 399..494
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
SQ SEQUENCE 525 AA; 58358 MW; 48E9F3E3BD377E9F CRC64;
MAQIRRIQPI PSESMFSTSG LQEVIRGNLS SEKSGNRSIQ FDSFQHLDEE RENAILISVL
RQTLLPFFVA GLGQICTGLF FERAQHWWLF LYVPETFILV PALLGLKGNL EITYASRFCT
LSNTGRMNEA KEVFVIARFN FCLIELQAII LSFFAALLSS AIGLINCNFN QSHAMVILSS
SIYTAFLSSL IIGFVMIAIV VSTRRYGIDP DNITAPLTAT LSDFITLIML IGMGTLVVHM
YIGNLYILNI AMVIFLLCIT PFLTYYAAKD PRTRAVLKDG WFAVTAAIIV GCCSGLLLQS
AIVVFPGIAA LHPLIAGLAG NRVSVQSSRL ATALHLSKYS LGTLPAGTTI WTSLNPLRFF
CLRHVMNEKF HRNALVVAGH QRGIMTKIGD YDTVGTNSIL KNLDSKVAFL LLVTAIPYNF
LFVTVVIFTA QNIDFSWILV GGYILAAFIQ GLLLFYLCQV TVYGLWWFRL DPDNSSVPVL
TSLGDLFGIG LLYIVFLFLH RFAPSTVLYQ RYQTMNITRE CGIDF
//
