ID A0A182E378_ONCOC Unreviewed; 1991 AA.
AC A0A182E378;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=ANK_REP_REGION domain-containing protein {ECO:0000313|WBParaSite:nOo.2.0.1.t02433-RA};
GN ORFNames=NOO_LOCUS2433 {ECO:0000313|EMBL:VDK66299.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t02433-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t02433-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK66299.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; UYRW01000382; VDK66299.1; -; Genomic_DNA.
DR STRING; 42157.A0A182E378; -.
DR WBParaSite; nOo.2.0.1.t02433-RA; nOo.2.0.1.t02433-RA; nOo.2.0.1.g02433.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08317; Death_ank; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF33; ANKYRIN 2, ISOFORM U; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 24.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 156..188
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 189..221
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 222..254
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 255..278
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 317..349
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 350..382
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 383..415
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 416..448
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 449..481
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 482..514
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 515..547
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 548..580
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 581..613
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 614..646
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 647..679
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 680..712
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 713..745
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 746..778
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 779..811
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 812..844
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 845..877
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1137..1294
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1296..1440
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1635..1716
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1955..1991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1970..1991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1991 AA; 220020 MW; 60257F2CE1BAE7D7 CRC64;
MWIQQKFCRR VTDTTKLLMS DPVVEASGWP AEPPESQHQQ IPADNSQHSN KVLLYNCVPS
KENCIIVRYF YYEKVSKNSK CQQLRQLIDF CGIMRPLQWK TQSFPIFAFF KACLNCLKPG
HGESSASFLR AARAGNLDRV LELLRSGTDI NTCNANGLNA LHLASKEGHH EVVRELLKRK
ADVDAATKKG NTALHIASLA GQELIVTILV ENGANVNVQS LNGFTPLYMA AQENHESVVR
YLLAHNANQV LATEDGFTPL AVALQQGHDR VVALLLENDT RGKVRLPALH IAAKKDDTKA
ATLLLQNEHN SDVTSKSGFT PLHIAAHYGN ENVAQLLLEK GANVNYQARH NISPLHVATK
WGRANMVSLL LAHGAVIDCR TRDLLTPLHC ASRSGHDQVV DLLLEKGAPI NAKTKNGLAP
LHMAAQGDHV DSARILLYHR APVDDVTVDY LTPLHVAAHC GHVRVAKLLL DRNADPNARA
LNGFTPLHIA CKKNRIKVVE LLLKYHAAIE ATTESGLSPL HVAAFMGAIN IVIYLLQQGA
NADVATVRGE TPLHLAARAN QTDIVRVLVR NGAQVDAAAR ELQTPLHIAS RLGNTDIVVL
LLQANASPNA ATRDLYTPLH IAAKEGQEEV AAILMDHGAD KTLLTKKGFT PLHLAAKYGN
LPVAKLLLER GTPVDIEGKN QVTPLHVAAH YNNDKVALLL LENGASAYAT AKNGYTPLHI
AAKKNQMDIA STLLHFKADA NAESKAGFTP LHLAAQEGHH EMAALLIENG AKVGAQARNG
LTPMHLCAQE DRVSVAEELV KENAAIDPKT KAGYTPLHVA CHFGQINMVR FLIEHGAPVS
ATTRASYTPL HQAAQQGHNN VVRYLLEHGA SPNVHTSTGQ TPLSIAERLG YVSVVEALKT
ITETTVITET TTVTEERYKP QNPEAMNETM FSDSEDEVFV IVLLDAAAIV VVVAVVVVER
LFVDSAPNTL EEDASHLRAL AHSPLRLSTS DDHDLSFFPN HTSSPYPSPG ATLIYLSHEY
RMEENSLRYL RHDLDIVDIV KESVIGEDNQ ITANAHTHDF SESLTKGLHD STGLHLIHAT
EQILSRSPEL EGTDGDLDAL IRKAQHEPIT TAMADPSLDL SLPDNVAITK TTVQPSFLIS
FMVDARGGAM RGCRHSGVRI IIPPRKASQP TRITCRYLRK DKLTHPPPLS EGEALASRIL
EMAPHGVKFL GPVILEVPHF ASLRGREREI VILRSDDGQH WKEHQLEATE DAVQEVLNES
FDAEELSQLD DLHTSRITRI LTNDFPMYFA VVTRVRQEVH CVGPEGGVIL SSVVSRVQAI
FPDGSLTKTI KVSVQAQPVP QEIVTRLHGN RVAVSPIVTV EPRRRKFHKP ITLCIPLPQS
SNKGMLTQYS GQPGQEPPTL RLLCSITGGS APAQWEDITG TTQLTFTGED VSFTTTVSAR
FWLMDCQTPR DAARMAQEVY NEAIAVPYMA KFLVFARRTF PTEGQLRLFC MTDDREDKTL
EKQENFIEIA KSKDVEVLSG RHQFLEFSGN ILPITKSGDQ LSLYFLPFQE NRLAFMIKTR
AQTDYEAAVD GRIAFMKEPK MRAENLPPQT PLCTLAITLP EYTAPEPMVY KKPFDSEVPL
TEKYAGAFHE TTEPDDLPLA HVARLTGADW HRLARALEVP DADIRQVRHQ LVGLEAIAIL
RIWIFLKKEQ ATPAALRSAL QRIGRDDVVR EMNRTEKPDD LEGIPVSHVS GPSVTVSSTS
LEAVDGRHRY AEIKKHLKSL EVTTAQQQMA QEPFFQQTEY YGIHDDAEEP KEQPSREEEE
VAVSEIRTVV RTERHVHDSE DGPIVEERTI TTTYEDDVAV NEEIVDRIVP LNKEEQEKWD
RMIREAEMNL DQQETPKEEA LGYQVIHEEK EGDDGTIQKT TEIKNSHVTQ VLFDGAETSA
NEARSDSGDA STIIIPTSKE DNHVIGMETK CAAEHKHQCS NSSSSHDAVD FSDVMEERRT
DEEARGQSVH E
//
