ID A0A182E4P7_ONCOC Unreviewed; 735 AA.
AC A0A182E4P7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Alpha-type protein kinase domain-containing protein {ECO:0000313|WBParaSite:nOo.2.0.1.t02968-RA};
GN ORFNames=NOO_LOCUS2968 {ECO:0000313|EMBL:VDK67551.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t02968-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t02968-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK67551.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYRW01000518; VDK67551.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182E4P7; -.
DR STRING; 42157.A0A182E4P7; -.
DR WBParaSite; nOo.2.0.1.t02968-RA; nOo.2.0.1.t02968-RA; nOo.2.0.1.g02968.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004686; F:elongation factor-2 kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd16967; Alpha_kinase_eEF2K; 1.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR047588; eEF2K_a_kinase_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR45992:SF2; EUKARYOTIC ELONGATION FACTOR 2 KINASE; 1.
DR PANTHER; PTHR45992; EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SUPFAM; SSF81901; HCP-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 116..324
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
SQ SEQUENCE 735 AA; 84610 MW; 9C1856786F7DE232 CRC64;
MDSTENYMKY ISSTSELQSD GIQNEHLDDS TEWQLLEPLC DVSEAVKQKF GPLDSLDNGD
FQQFEFNQHS SHLSERNREL IHRWQQLATW CAKHPDDPWV KFHFDTLPVR NCKRHRYSSI
HQCWEIDNVQ VKLHPEPFAR GAMRECYRLK KLGSRDKNDD WDHAQNYVAK KYIRSVDKEV
LFEDVKLQMD SKLWAEEFNR HHPPKKIDIF QVCILEFLDE EHAFYHLERF IEGEYIKYNS
NSGFVADVCR KTPQAFSHFT FERSGHQLIV VDIQGVGDLY TDPQIHTATG EGYGSGNLGT
RGMALFFHSH MCNDICRSMC LTEFDLSEGE RNALKRGVNV ERNWNSLTRS SSNRPASICS
SLVEERGDAM EKLRRRTVSV NSSGRRSSAS SFCDEHSTDT QHSDVRLSYD CFEQVLYDSD
KSMAKRFTSS CSSNLFDSVD NEAKEVMCQD PQVGSLSSCS SRMTREAERE AYWFEKRKLS
RPAGLLSESK INELSEFSQK IHGTNCILGQ IHLDLARYHE LGQFVDKSTF VCSEIENIYS
TKDYGNKKNA GNYIDYDKDA AFYHLDIARR CGVLEAIITM AKMAFGQSHE LLKEVICEEV
WENDDLQGTG FELMECAANM GDQSAVIFIA QAYETGRFLG PMKKPSWPKA VIWYEKALNF
LQSSETNENE TPHEGVRPRY ELLERMAIMY KEGGYGLLQD LTKAYDLYTE AAVSATEAMR
GKLANKYYEL AEQCV
//
