ID A0A182E583_ONCOC Unreviewed; 960 AA.
AC A0A182E583;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Retinoblastoma-like protein 1 {ECO:0000313|WBParaSite:nOo.2.0.1.t03160-RA};
GN ORFNames=NOO_LOCUS3160 {ECO:0000313|EMBL:VDK68207.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t03160-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t03160-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK68207.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR EMBL; UYRW01000577; VDK68207.1; -; Genomic_DNA.
DR STRING; 42157.A0A182E583; -.
DR WBParaSite; nOo.2.0.1.t03160-RA; nOo.2.0.1.t03160-RA; nOo.2.0.1.g03160.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051172; P:negative regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742:SF36; RE32990P-RELATED; 1.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 124..247
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 423..623
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 706..789
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 800..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 960 AA; 109280 MW; D81FAD2ED40E33D7 CRC64;
MPGKDTSDGV WVLGCSVSLG STGESRELPV VSYMAEDSDI KSETFIKSPS AGQSEIADKS
QLNPTTAFLD ICKQLDPEIN EDFVEKAWKQ YDTIEKQYVL EGKQLTWYAC AVYLSMWQGN
PLERVVPKKY SLSEILRICK ISVLEFFEKV TKWVEMVNGP RRLKDHISRV QSSLAVVAVV
FKKLLPIFRK IFAPPCSNDD NTKGLNCKKL FALIWTLFIV MRKQFNSDDL MNSFHLLLCT
VDFVFQDLRR SELTCLLDGD FINAIEMQPE EDSILEILCQ IFEGVVLDAK HFRTHCWLPR
IRRMSEEKAI EANKDLTNFV ANEFINKKKL DSMYEELIVK RGEMDERMFL PADISVVFDE
AYDECAVQRL RRSEDGDSLV DADMLLRLST QSCLERLQDQ RQQRTPLSGR GYVISAEQYC
PATPIAASLY NASKLEALLQ DNYRRLDVEV ESILCHSCQD PLGKIMNIVS QLSERLEEVV
ENEGQSEGAN YDTTFREMFA VRKSNTECLF FRFLHKIALS EKDRLGSGSI VKLSAVLLRN
DFLKALYVCA LQLVLFTYES IREFPWSLEI MRLPSIHFYK VIELIIRADS SLSREMVKHL
NKVEERVLEE FAWSLDSPLW PSLQRRVDGV PSSQAVSLET VEGYSMRQPS LSQRYTLSPM
KPLAAKRRLE FDDSDSSCVA AKRRAPDVEN PTPTSPTLLF FRKAPVRLRD LCERVRLDEK
GRQRAWTLFE HVLRAETSLM AGRHLDQNLM CCLYVVAKIG QQNISFHDIM YHYRHQPQAA
SRVYRRVLVE STSSPPIILD DGASHDSVGS ASGDKFRSDS SVSGAITGSG TATPEHQNVE
YIDLIKYYNQ FFIARVKSFV QKLQPGFAES GVSLLSIPVV QCNRLSPQRS VSDRITVTPM
PSSLPSSPSR PYRYIFDKTP VKELNSINLI MHSAGRTIPQ LASGGFHQGS YRNLVARTIS
//
