ID A0A182E9N6_ONCOC Unreviewed; 1156 AA.
AC A0A182E9N6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Actin-related protein 2 {ECO:0000313|WBParaSite:nOo.2.0.1.t04749-RA};
GN ORFNames=NOO_LOCUS4749 {ECO:0000313|EMBL:VDK74347.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t04749-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t04749-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK74347.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the actin family.
CC {ECO:0000256|RuleBase:RU000487}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; UYRW01001125; VDK74347.1; -; Genomic_DNA.
DR STRING; 42157.A0A182E9N6; -.
DR WBParaSite; nOo.2.0.1.t04749-RA; nOo.2.0.1.t04749-RA; nOo.2.0.1.g04749.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 4.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 3.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00022; Actin; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 3.
DR PROSITE; PS00432; ACTINS_2; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 491..628
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 655..834
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 840..1122
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
SQ SEQUENCE 1156 AA; 132656 MW; 33539CB9F91BF264 CRC64;
MDSQGRKLLV VDNGTGFVKC GYAGTNFPAH IFPSVVGRPL VRSSQKVGNI EIKDLMVGEE
CTQLRQMLEC SYPMENGIVR NWDDMGHVWD YTFGPEKMDI DPKDCKLLLT EPPLNPSGNR
EKLFQVMFEQ YGFNSLYVAV QAVLTLYHQG LLTGVVVDSG EGVTHICPVY EGYALNHLTR
RLDIAGRDIT RSSGILIILL LSIPFSQSSM CDPPTRCYFQ LLLLRGYAFN HTADFETVRL
LKEKLCYVAY DVEKEQRLAL ETTVLTESYT LPDGRVIRVG GERFEAPEIL FQPHLINVER
SGLSELLFGV IQSADIDTRL EFYKHIVLSG GTTMYPGLQS RLERELKQLY LDRVLRGNTE
AFQKFKIRIE APPRRQHMVF LGGAVLANIM RDRDADFWIS KEEYEEGGLE RCLRKLGISF
VTADRFCSIV YRYTLVLLIR NLHFLPVHFI QSMSTKISPA ADVIARRYDN VIKSKEDKRE
YRGLELTNGL RVLLISDPET DKSAASLDVN VGHLMDPWNL PGLAHFCEHM LFLGTDKYPS
ENEYSKFISS HGGVTNAYTA TDHTNYHFDI APEHLHGALD RFVQFFLGPQ FTESATEREV
RAVDSEFSNS LFNDEWRILQ VERSLSKPSH DYGKFGVGNR TTLLVDALKN GIEPRKALLE
FHKTYYSSDI MSFAVLGKES LNQLEQMVTS LSFGDIGKKN VSRKIWNEGP YGEEQLGVKI
ELVPVKDLRY LNLTFPIPDY RDDYRSWPAH YVSHLIGHEG PGSLLSELKK RGWVNSLSAG
DHLLARGFGS FSISVDLSEE GLLHTDDIVE LVFNEVSLVK QTGPLKWIFD ELRQLQEIKF
RFKDKENPLN YVTHISSELQ RIPFEDVICA DYKMDLYKPD LIKEFIEHLK PKNMIYAVIS
QEYAGKKGNI KEKWYGTEYN NTKIDKGILS KFNNALAQTP SFLSLPAKNE YIATNFNLKS
REQTRKLPYL VKNDDWSRLW FMQDNDFKLP KLDIRIAIKS PMMQSDPMNS YLSAMFVICL
QDAIAEETYN AHLAGLKSSF DLQSYGISLH VSGYDEKQQK YISDLIQRLI TFVPDEERYN
ILKETFCRNL RNFRQNQPYL QSHYYTTLIL GSRQWSKEEI LACAEKTEVE RLQRFTRESL
QALQIEMLVC GNSTEK
//
