ID A0A182EBM0_ONCOC Unreviewed; 1063 AA.
AC A0A182EBM0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=DNA_mis_repair domain-containing protein {ECO:0000313|WBParaSite:nOo.2.0.1.t05454-RA};
GN ORFNames=NOO_LOCUS5454 {ECO:0000313|EMBL:VDK77570.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t05454-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t05454-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK77570.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- SIMILARITY: Belongs to the XPA family. {ECO:0000256|ARBA:ARBA00005548}.
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DR EMBL; UYRW01001454; VDK77570.1; -; Genomic_DNA.
DR STRING; 42157.A0A182EBM0; -.
DR WBParaSite; nOo.2.0.1.t05454-RA; nOo.2.0.1.t05454-RA; nOo.2.0.1.g05454.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd21076; DBD_XPA; 1.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR Gene3D; 3.90.530.10; XPA C-terminal domain; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR000465; XPA.
DR InterPro; IPR022656; XPA_C.
DR InterPro; IPR037129; XPA_sf.
DR InterPro; IPR022652; Znf_XPA_CS.
DR NCBIfam; TIGR00585; mutl; 1.
DR NCBIfam; TIGR00598; rad14; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR Pfam; PF05181; XPA_C; 1.
DR Pfam; PF01286; XPA_N; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 470..607
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 893..1035
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 637..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1063 AA; 120811 MW; 85DDEE63C7ECC549 CRC64;
MKRQRVEGHV NNGDGYIPYV EKLYRKTQGN YEEAGGFMDD DDEYASIRER IAEARQKRAD
EAAANSGSLV PPDNCIDCAK PLCNSFLWEK FNYPVCDTCR NDKGAHKLIS RTEAKNEYLL
KDCDFDLRKP VLRFISKKNP HNPRYGDMKL YLKAQLEQRC LEVYGSKEEF EKAKETRSTQ
KETRLEKRFE KKIKEMRQQV HGSKIFKTGY GKAHDHVYGD ETYDAKKDEY WKICKICEYK
LTFGLMENAD RQVIGAKIHA ISADVCRKIC TGQVIISLAS ACKELIDNSL DAQARTIEIR
VKKMGFERME VIDDGIGIHP INFDALCKPH STSKLANFSD FNQLTTFGFR GEALNSLCVV
SSLSITTRHT DETMATKLHF DHDGSITSRE KCARPVGTTI SINNLFETLP VRRKEFERTV
KKAFTKLLNV VQSFALSRTD VRFVVNSLMD GKQHQALVTP GGDASIKDII VNLFGARFEK
GTILDIIQQE PDESICALYG ISDHSKFDDI RITGYISSCV HGHGRSTADR QFVYFNKRPV
DYAKLCRIAN EVYQQYNRGQ YCMLILFVDV PPETIDVNVS PDKRSVFFER EKQLFALLRA
SLLATFAPHL GHVDISSQST NDLSHLESMN DSFIHLTQPN DNNDSFDVST QNSVSSSESK
NTDPPTAMSF ARDKSRGPSI NLMNIKETIE KTRKRPASNN CSEKPTSVQK RPAANLFEKF
AFKVIPHSSN EVMVDNCSNS EASLESSSVV DQREKDDFRE TSLRTVVAGA SKDENNVIMP
QEDANFPDLS DDDDDDDVLV TAMKDDENCK SILKAESSCG TTRTQQTISF SMFDLKNHMN
KLRLEASKVM SNICDSDDRA MESRTEFRID NPEIAESELA AYISKKDFET MEILGQFNKG
FIIVRLNTDL FIVDQHASDE KYNFERFQKK ARIQTQQLIS PRVLDLGVVK EAILRDNVDI
FNYNGFEFRF DDEEVVGKRA LLTAIPVLQS WQFSISDIDE MLSVLCDFPG MMYRPAKLRK
LFASRACRKS IVRHLGTLDH PWNCPHGRPT LRHLCALGSK TSD
//
