ID   A0A182ECH9_ONCOC        Unreviewed;       593 AA.
AC   A0A182ECH9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Phosphatidylinositol 3-kinase catalytic subunit type 3 {ECO:0000313|WBParaSite:nOo.2.0.1.t05773-RA};
GN   ORFNames=NOO_LOCUS5773 {ECO:0000313|EMBL:VDK79369.1};
OS   Onchocerca ochengi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t05773-RA};
RN   [1] {ECO:0000313|Proteomes:UP000077448}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22919073; DOI=10.1101/gr.138420.112;
RA   Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA   Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA   Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT   "Analysis of gene expression from the Wolbachia genome of a filarial
RT   nematode supports both metabolic and defensive roles within the
RT   symbiosis.";
RL   Genome Res. 22:2467-2477(2012).
RN   [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t05773-RA}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:VDK79369.1, ECO:0000313|Proteomes:UP000271087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UYRW01001626; VDK79369.1; -; Genomic_DNA.
DR   STRING; 42157.A0A182ECH9; -.
DR   WBParaSite; nOo.2.0.1.t05773-RA; nOo.2.0.1.t05773-RA; nOo.2.0.1.g05773.
DR   Proteomes; UP000077448; Unassembled WGS sequence.
DR   Proteomes; UP000271087; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048:SF111; PHOSPHATIDYLINOSITOL 3-KINASE AGE-1; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          45..232
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          298..579
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
SQ   SEQUENCE   593 AA;  68434 MW;  9D93CB61808E3726 CRC64;
     VGSNDNRDTV RIEVEFEDYG YIRFPDMDSV CEYVEKLDAR NAKLPLPALS SPVNSTKQFL
     DSLHFVDAEY LTDKQMERLW EARELIAQYK PDLLPLIAHC PLIWTRRDEF SRLYELLKRW
     GNIQPETALV LLGIKYPDIK IREFAVDSLD NVLDNDRLQL YILPLIQVLK FEPYGSCALS
     RMLLKRALCN NRIGHILFWL LRAELGQLSE VGQDLTRNYK RFALMVEAYC RANYTHLNSM
     LRQVDMVVRL TNLSKIIKTM KDNECATKHL QKELASYVGI MQDMISPLDI SNSLGTLNIE
     MCKVIGSAKQ PLRLAWTNPE PLARLHNETH QIIFKNGDDL RQDMLTLQVM RIMDALWKSQ
     DYDLCLSIYE VGMICVVQNC STLFEIQCAA KQLGSTFSME SGLINKYIRN HSENSKVYLE
     GVDRFTASCA GYCVATYVLG IKDRHQDNIM LAKDGRLFHI DFGHFLGHYK KKLGINRDRV
     PFVLTDHFLC VIAKGKSNFR DSHEYKKFKK LCTDAYIILH QRSKLFISLF SMLLCMGLPE
     LQKAEDIDFL KGTLCSDMDS NHAAASFNKI FEEAFSGAWS TKTNWFFHSV KHL
//