ID A0A182ED40_ONCOC Unreviewed; 564 AA.
AC A0A182ED40;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Protein kinase domain-containing protein {ECO:0000313|WBParaSite:nOo.2.0.1.t05988-RA};
GN ORFNames=NOO_LOCUS5988 {ECO:0000313|EMBL:VDK80381.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t05988-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t05988-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK80381.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; UYRW01001743; VDK80381.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182ED40; -.
DR STRING; 42157.A0A182ED40; -.
DR WBParaSite; nOo.2.0.1.t05988-RA; nOo.2.0.1.t05988-RA; nOo.2.0.1.g05988.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:InterPro.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.10; -; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR001182; FtsW/RodA.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR PANTHER; PTHR11668; SERINE/THREONINE PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR11668:SF492; SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-DELTA-RELATED; 1.
DR Pfam; PF01098; FTSW_RODA_SPOVE; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF00069; Pkinase; 1.
DR PRINTS; PR00114; STPHPHTASE.
DR SMART; SM00156; PP2Ac; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 536..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..125
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 564 AA; 64217 MW; DF84D0A84D221102 CRC64;
MENIVLDFDG HIQIVDFGFS KKLADGERTR TVCGTLQYMA PEIAEEKFYG KEVDWWSYGV
LLHILNTNNY PFPNCDVNSH IELRYDSYST PCCEPMLGDL FNKLLNVNIE QRIHTFAQVK
FHPFFESINW DDVALKKLVP FAHIEKLRRC PSCNSLYDKS VSDFSDTDAE ENWAAFEERY
EESKLKKAAG NTKLRLSRIH DLSIRLLNAS LQKGTHLRSI VKEEELIELL HDTKVVLQSQ
STLIEINAPV VVCGDIHGQY SDMLRIFDKC GFPPEANYLF LGDYVDRGNH ECAGINRVYG
FYEEINRRYH SVRLWEVFQD TFNYLPYAAC IAGKILCMHG GLSPKLNDLD SLRNIERPSD
PEPTSMELDI LWSDPEEGVQ GWQPNSRGVS FTFGVDVLKH VCEKLNIDLV ARAHQVVQDG
YEFFGNRRLV TIFSAPHYCG EFDNAAAAMN VAEDLSCSFH VTICFFLRPY HKQRILSFLD
SSTDPLGTGY NAQQSQIASG SGGLFGKGFA NGSQTQLGFL PERRTDFTFA VLREEWGFLG
SMVLIFLYTT LLAIIFSVAH RPKV
//
