ID A0A182EED6_ONCOC Unreviewed; 672 AA.
AC A0A182EED6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=E2F_TDP domain-containing protein {ECO:0000313|WBParaSite:nOo.2.0.1.t06441-RA};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t06441-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t06441-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR STRING; 42157.A0A182EED6; -.
DR WBParaSite; nOo.2.0.1.t06441-RA; nOo.2.0.1.t06441-RA; nOo.2.0.1.g06441.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF7; TRANSCRIPTION FACTOR EFL-3; 1.
DR Pfam; PF02319; E2F_TDP; 2.
DR SMART; SM01372; E2F_TDP; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 174..242
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 337..426
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 76242 MW; 468F18C435DC577D CRC64;
XDQSDYKKPN RSRDEIKWNG NEFRNQVDNE KSDGSGDEIK WNGNILKDSN DIKESNEKRD
KIKMNSNILI DHSDGERLDE NGNKIKWNGN AYSDQDGNLN GNNDDVEYNE NIFGSENRDE
ELNENGGEIE WNGNVLINQN EVEESDRNVE WNGQNGNAAR HQKGEEESNN GFPRKTKTLG
LLCRKFFLKV LEYVDSGDDK INLEVIACSM EVEKRRIYDV VNVMEALGAM EKSHKSFYTW
KGLDNLPSTL HTLKIEAEKE GIYEKVLLTQ HIMTRFMEVP NKNGNVNASP SEAGPSRTSD
DKIISTLERS NSAGNKDSGS VSSKQSGLKK KESKRQRGLN SLTYLCKYFF KILIVGLDYQ
PDYKVSLDVA STILIKDPDI DGCKPPDRSR CRRIYDVANV LISLRLIERR MFTFGTKKIP
LFVYCGPNIT ENGKFDFFYH IRFNKLSVKL KNSEEKRAYE VEEENLETFF RKQKEKKKEA
ESSAEIGEPA KKRSRIEETD PVRESIDFGK ENIPSTLINK RIAPDSPLVV SIVRPQPQAS
SSFNALQSVV QQPRFTQFIP LPICPAGFLP FDPNIIFLNN GVSTTRIPMQ QNFNYLNAYP
LSSMAFSQQP RGPIIDTANM SYTAYSNSNS SFTSAGNILR PSLFNIDAIL GNRETHENNQ
VAGEIKFAAS IV
//
