ID A0A182EIM4_ONCOC Unreviewed; 694 AA.
AC A0A182EIM4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Cleavage and polyadenylation specificity factor subunit 3 {ECO:0000313|WBParaSite:nOo.2.0.1.t07955-RA};
GN ORFNames=NOO_LOCUS7955 {ECO:0000313|EMBL:VDK87823.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t07955-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t07955-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK87823.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; UYRW01003071; VDK87823.1; -; Genomic_DNA.
DR STRING; 42157.A0A182EIM4; -.
DR WBParaSite; nOo.2.0.1.t07955-RA; nOo.2.0.1.t07955-RA; nOo.2.0.1.g07955.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR CDD; cd16292; CPSF3-like_MBL-fold; 1.
DR Gene3D; 3.40.50.10890; -; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR022712; Beta_Casp.
DR InterPro; IPR021718; CPSF73-100_C.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR011108; RMMBL.
DR PANTHER; PTHR11203; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11203:SF11; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3; 1.
DR Pfam; PF10996; Beta-Casp; 1.
DR Pfam; PF11718; CPSF73-100_C; 1.
DR Pfam; PF16661; Lactamase_B_6; 1.
DR Pfam; PF07521; RMMBL; 1.
DR SMART; SM01027; Beta-Casp; 1.
DR SMART; SM01098; CPSF73-100_C; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087}.
FT DOMAIN 25..238
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
FT DOMAIN 250..371
FT /note="Beta-Casp"
FT /evidence="ECO:0000259|SMART:SM01027"
FT DOMAIN 481..687
FT /note="Pre-mRNA 3'-end-processing endonuclease
FT polyadenylation factor C-term"
FT /evidence="ECO:0000259|SMART:SM01098"
SQ SEQUENCE 694 AA; 78046 MW; 1A1E1F7AD3B859EB CRC64;
MDTDGMDDFS DTLVITPLGS GQEVGRSCHY LTFKGKKILL DCGIHPGMSG VDALPFVDFV
DCEELDLLLV THFHLDHCGA LPWLLEKTAF RGRCFMTHAT KAIYRMSIGD YLKVSKYGGS
SDNRLLYNEE DLEKSMEKIE VIDFHEQKEV NGIKFWCHVA GHVLGACMFM IEIAGVRILY
TGDFSRLEDR HLCAAELPTV SPDVLICEST YGTQIHESRD EREKRFTSIV HEIVGRGGRC
LIPAFALGRA QELLLILDEY WETHPELQDI PVYYASSLAK KCMAVYQTFV SGMNSRIQKQ
IALNNPFVFK HVSNLKSIDH FEDVGPCVVL ASPGMLQNGL SRELFENWCT DSKNGCIIAG
YCVEGTLAKH ILSEPEEIVA LNGQKLAMRL QVAYISFSAH TDYTQTSDFI RALRPPHLVL
VHGEMNEMNR LKAAIIRQYE DESDFHIEVY NPRNTESVEL HFRGEKTAKV VGKMAMSPPR
DGQILSGVLI RRNFNYHLMH ADDLSAYTDL SSSILTQRES VFYSGTITLL LHNLQQVAGD
VCFDEIDSKD TSDPTHSIKL FDERIHVLVY YSQHVAIIEW TSNPVSDMFA DATLAAILHA
QTNPVPDKNL AKWNVKPNEI ECLMKTLSEL CGDEAIIRNT GNTIELKVDG KEAKIDLDTM
HITCTDQLLH HLISSVCQKM MNSLLPVCTL TVAK
//
