ID A0A182EK12_ONCOC Unreviewed; 771 AA.
AC A0A182EK12;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN ORFNames=NOO_LOCUS8447 {ECO:0000313|EMBL:VDK89344.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t08447-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t08447-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK89344.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; UYRW01003534; VDK89344.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A182EK12; -.
DR STRING; 42157.A0A182EK12; -.
DR WBParaSite; nOo.2.0.1.t08447-RA; nOo.2.0.1.t08447-RA; nOo.2.0.1.g08447.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582:SF47; NETRIN RECEPTOR UNC-5; 1.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 196..221
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 1..35
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 368..516
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 699..766
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 771 AA; 86298 MW; AECBD0158F179621 CRC64;
MIIANDGSLI ISAARLSDSG NYTCEARNIA NKRFSDPAQI IVYVNGEWAE WSSWNGNCKV
DCGQLKQEII RRRSGTVHTK LDDIWPKLVR RRTCNNPAPL NGGSDCLGDP EQTNECPLDC
HLDGYWSEWS SWSQCSENCQ KFRTRSCNSP RPTSGGQLCS GRDLDTKNCT EGEGYCIATS
QRPSPTYIGY SLEAQIAMYA GLFSVLILLL IILILIFILL YRCRRRYSDS KKDGFYFAEN
SGHVRTVLLQ QQQQRLLGDP TDSLKSMPKG GSEFYTLTTT ASPTHPLVRP PSLTLRSANS
SGYSSTRKIT GSRMALITES SSNSSNGKIT IARTNSRTSD ENYATLYDCV GDANDQYGSF
ELSKQSHVVL PAYVDSTGGR LLLKRSGAAL LIPEGAFQTN HMIFLAVSDD LNDSPKLLEG
NTVLSAVVMI GLCDENENDV VIHRPFIVTF KHCANIFPKD NWIFMIYAKG NQSNNWEMVA
QIGDEDINTP LYCQMDLTRC HIMIERFCKL LLVGKPRRPT LAAMKRMRLA AFGSLHRISN
DTSIRVYCVP ETGIAIQNVL RQEENTGALL AETENFLMRE KGALCVCLEE MSTGLIKKPE
AQYLEIPSSH HLWCVQNGLH CSLKTDVPED LLETITGRIV IYQKGNADAR EVLHFDMQQS
FEDSEMEEDG VLSSGFLLDY ATRRKLAELF DVPTDPTKDW RGLAKKLNLH RYIQYFATRP
GLSPTSLILD LWEAVEFGSQ RAVLDLLQTV RIMGRPDAVT VLESYLSSLK K
//
