ID A0A182EKA2_ONCOC Unreviewed; 489 AA.
AC A0A182EKA2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Regulator of G-protein signaling 7 {ECO:0000313|WBParaSite:nOo.2.0.1.t08537-RA};
GN ORFNames=NOO_LOCUS8537 {ECO:0000313|EMBL:VDK89570.1};
OS Onchocerca ochengi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=42157 {ECO:0000313|Proteomes:UP000077448, ECO:0000313|WBParaSite:nOo.2.0.1.t08537-RA};
RN [1] {ECO:0000313|Proteomes:UP000077448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22919073; DOI=10.1101/gr.138420.112;
RA Darby A.C., Armstrong S.D., Bah G.S., Kaur G., Hughes M.A., Kay S.M.,
RA Koldkaer P., Rainbow L., Radford A.D., Blaxter M.L., Tanya V.N.,
RA Trees A.J., Cordaux R., Wastling J.M., Makepeace B.L.;
RT "Analysis of gene expression from the Wolbachia genome of a filarial
RT nematode supports both metabolic and defensive roles within the
RT symbiosis.";
RL Genome Res. 22:2467-2477(2012).
RN [2] {ECO:0000313|WBParaSite:nOo.2.0.1.t08537-RA}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDK89570.1, ECO:0000313|Proteomes:UP000271087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Laetsch R D., Stevens L., Kumar S., Blaxter L. M.;
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UYRW01003620; VDK89570.1; -; Genomic_DNA.
DR STRING; 42157.A0A182EKA2; -.
DR WBParaSite; nOo.2.0.1.t08537-RA; nOo.2.0.1.t08537-RA; nOo.2.0.1.g08537.
DR Proteomes; UP000077448; Unassembled WGS sequence.
DR Proteomes; UP000271087; Unassembled WGS sequence.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF6; LP21163P; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000271087};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 37..112
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 399..489
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 270..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 56654 MW; 8CA2052AD7BFDF83 CRC64;
MALPRLRANA SIEEKMIHPN HMIYQKLENL VQTMLDPENG VPIKTVKSFL SKIPSVFTGQ
DLIAWIMKNM NMTDLADALH LSHLIASHGY LFQIDDHVLT VKNDGTFYRF QTPYFWPSNC
WEPENMDYAV YLCKRTMQNK AHLELEDFEA ENLAKLQKMF SRKWEFIYMQ AEAQYRVDKK
RDRQERQILD SQERAFWDVH RPVPGCVNTT EVDFRKLSRS GRPKYSSTTH AAVASCSNIT
LPYSTSAAAA HAAAQAPSCS SSILNGAANS SSSVTSQQPS SYVLPSQSVR PYSQRPGIRR
CTRLQDTLKQ EISALEARLT KNVLKTSKVV EKQVFHLIFY LQYFDHRRVF DPFLIQPGTA
ADQFQSHPNP WISDTVDYWQ HDKITGDISM RRLKLWEESF EELLCDEIGR ETLQKFSDKE
YSGENLRFWW QVQKLRKCAC RMVPVLVTEI YNEFIDKNAT SPVNIDCKVM EQTEENLKNP
NRWSFDEAA
//
