ID   A0A182F0Q7_ANOAL        Unreviewed;      1364 AA.
AC   A0A182F0Q7;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=PIN domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles albimanus (New world malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB000030-PA, ECO:0000313|Proteomes:UP000069272};
RN   [1] {ECO:0000313|EnsemblMetazoa:AALB000030-PA}
RP   IDENTIFICATION.
RC   STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB000030-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
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DR   STRING; 7167.A0A182F0Q7; -.
DR   EnsemblMetazoa; AALB000030-RA; AALB000030-PA; AALB000030.
DR   VEuPathDB; VectorBase:AALB000030; -.
DR   VEuPathDB; VectorBase:AALB20_028834; -.
DR   VEuPathDB; VectorBase:AALB20_029758; -.
DR   Proteomes; UP000069272; Chromosome 2L.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR   CDD; cd09884; PIN_Smg5-like; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 3.15.10.30; Haemolymph juvenile hormone binding protein; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR   InterPro; IPR019458; Est1-like_N.
DR   InterPro; IPR045153; Est1/Ebs1-like.
DR   InterPro; IPR010562; Haemolymph_juvenile_hormone-bd.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR038606; To_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR15696:SF0; PINC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR   Pfam; PF10374; EST1; 1.
DR   Pfam; PF10373; EST1_DNA_bind; 1.
DR   Pfam; PF06585; JHBP; 1.
DR   Pfam; PF13638; PIN_4; 1.
DR   SMART; SM00700; JHBP; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          66..195
FT                   /note="Telomerase activating protein Est1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF10374"
FT   DOMAIN          209..391
FT                   /note="DNA/RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF10373"
FT   DOMAIN          949..1020
FT                   /note="PIN"
FT                   /evidence="ECO:0000259|Pfam:PF13638"
SQ   SEQUENCE   1364 AA;  157039 MW;  090AFD97E6257067 CRC64;
     MEYSSNDVKQ LFRSVYTLVK GQDERKAELT ANEILEPSFQ LSHRLLISQC IQLIFEDFET
     VGVKSREILW RKGYYEVISV LKRQKGNIDG AVLQQAADQL IREGSNYFKA IVLRFAELFH
     LETLKYLVDF ALLDDYDDVA LRQEASCYSL LQLRNEAHAT SPQELYTKQE ISYALETIHS
     LLISLGDLHR YRLEFGLGQR AELRAQTRSY YLEAFKLNPK IGMPHNQLGM LVTGQNNNLD
     AVYHYLYSMC CVIPFECSEA NVNNIFQKNI RQLESAAAST DGGLADEDRA VKQFIATFLL
     VVDVFFYDKN VTDFTALCHS VLIDFKKVLS IRELLGDFLM TEDMIFKVVS ILFFCMHRIR
     MCNSDKIYSL NAFLVALCSE LLEYCTISVE KCIVEKVRDD NRFHELYLER YQQNDEKVLR
     TRAMAKHGMY SKDQKSSSGV EEGTGSQDSR GTNSKECMDG DSKGRAQRVH SAKKTSATNG
     GSIGRSKQKQ TRRRRRAFSN ESYSEDEEVG LHVDGDRDDD YSHHDYDSEH DFSSGSEASE
     DDDNVEDDED DEEDEEEEED VQDIMSLSSY GSYDSARDEE HQVGQVQNGK QHAKKKQFTE
     QQQDGEGDGD GNGRTRAVQD GEHLKFKKRY QKTNPNIVLE FANTDRTIRS LKILFDWLHC
     NMDVLFNCYQ SNPEFVEKIM KLLNYFNIDI FCNRIYFCRD LITVPGLRED LHSIFVARRT
     IPLREDIAMK RFPLFEPTQE GLLWETSYKY GMSAEDESLL RLMKMVDFGF AVLKTNKFDY
     CFDSKTREFS LRSARGRQTR VTAQKNKKKK HQALKREWNG AKQHPKPHSK QQQHGFSRDR
     QRHEKRRPRT DVHGERQPRI LQNDDDDPGD IFVFPSECRR SRMRNDSQQA SKRTANYGGG
     LGDELLEKPA KKDISTMMGK LWLEDQVKQL EAKVNRKGGD VLLTPYLMVD AKCLADYTSI
     VKNLVKMKKF IVLIPNAVLN ELDKLKKFNE GARSAIKWLE IELTKGNRFL RIQKPNESLP
     MPLVKIPKKL DREGALFTQI VQFCNHIVTT QGDDDGFEII TYLSGDSLAN KKLGNGSSYV
     GILEAIPVKF EQICNSLRIQ RKMKAMLLVC GVALWAGVAF AAPPTTSQIK DPEVELPTFM
     EICYRDSPDL SKCIQRSIQR MLPEMHTGIE SLGFPSLDPY ESKSTYIDYK RNQMSASLHV
     KNAKTYGISK AQILGTRATV TDKTFNLAVD VRFPQIFMEG YFKGEGRFNS IKLASKGYFN
     NTMTDVTTTW QMSGEVKQRN GEDYVEIDSF DMSPEVADMK VFATGLFPDA ELNQIALEFV
     NQYWPMFYKE LLPNSRQVWE PEMVALVNKI FQRIPYRRLL PKRE
//