ID   A0A182F552_ANOAL        Unreviewed;      1196 AA.
AC   A0A182F552;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS   Anopheles albimanus (New world malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB001594-PA, ECO:0000313|Proteomes:UP000069272};
RN   [1] {ECO:0000313|EnsemblMetazoa:AALB001594-PA}
RP   IDENTIFICATION.
RC   STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB001594-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A182F552; -.
DR   STRING; 7167.A0A182F552; -.
DR   EnsemblMetazoa; AALB001594-RA; AALB001594-PA; AALB001594.
DR   VEuPathDB; VectorBase:AALB001594; -.
DR   VEuPathDB; VectorBase:AALB20_029721; -.
DR   Proteomes; UP000069272; Chromosome 2L.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF51; ANOCTAMIN-8; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        319..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        430..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        513..536
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        664..685
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        715..737
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        749..771
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          308..784
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   1196 AA;  132855 MW;  02C5C3B110021207 CRC64;
     MDQHPLLLAN ENIHDSGIIE DVHQESEDTG NEDYGDESNL ESNLRRRKGK IISCVENGTP
     LPFASILATA FRQYPSSQRI RELTGNNEAW EMKLDSAASR LIRRRVPCAG HLMTPRRLWL
     NKIPTQCDVV IEFPEDAPDE ALRWLVSRIK ANPPEGLGLS AMLRAHESTK RTALYITAPM
     NVLFKAAEEA RLPKRLRHDL GGALKEFTKR ESHCFAQTKD SEGANSLFTS QERQWLVLQV
     LQGLRAGTAD LKALQGRAQV EEGQSIVAAW QELGLITQVF PLHETNALQQ LQSSWVRKFF
     APQPLDDIAA YFGVKVALYF AWLGHYTCAL CVPAVLGTIL YAGLWGRGQT AQDIGHVIFS
     LFNVAWASLY LEAWRRYSVE LAFRWGTLST PPELLEPPRP LYKGPLEESS VTGRLEPREA
     PAWQRRAFRY LVSFPIIALC LVLVFVVMFL MLRLQDWWDA KLPEQGVFSC LSVIPKVLLA
     GAITLMDEAY YKLAVWLNDR ENYRLQSKYE NHLIAKVALF QFVNSFLSLF YIAFYLRDQD
     KLKEQLAGLL ISRQIIGNLR ESAWPYLVEQ WRLAKLSFKM WGALSPTQEL PPTTITASSA
     ATAAAASPDG ADSKQQGEGH RSPSESSTTG TPKRSIGQAE IESSLYKYDG TFSDHLEMLV
     QMGYVVLFSA AFPLAGLCAL ANNLLEIRSD AFKLAHVHQR PFGQRVANIG TWQNALGMLG
     LAAVIVNCAL IGLSGQVSRL WPGLTSTQTV ILIVALEHVM LGLRSALTWL LPELPSWLAA
     EIARAEHCRR EMQCKGPSPR QTPPSPPSST SISHHDPDFN SNHDIFDKTE QSVGSHDNHR
     EDSELDRVAK LDNLSLQAAQ QLQQQTLQQH QQQQQQQQQQ QQPPKDTQNN SCDNMDIFAM
     DTRDVSPDSP ISQTSTVLLR PLQDSPLSGQ SAQTVALDST QTNSGACVKP PSIKLADIPP
     FRGEAMKHSC SIYDKRSINL GEPSQSARIA SKPIQIPEIP PFRKQAHSTM HSPVSSPSPQ
     ATQMLSANPS PPRIAEIPPF RPRQRSKEWM PNIEVGRLKQ QELATGSDSE LLKPAPSWTN
     VAIKANEPQP GTSNSAPSVK APTEEEAKAA ELAAKKSRLK QSLVKRARSV AIFSLKLKEQ
     RAKRAEKMAL EALEALPAPP PGGELSLIPI EQLIQVDDVL NQRNHASGSS HNNGHS
//