ID   A0A182F7Z2_ANOAL        Unreviewed;      1088 AA.
AC   A0A182F7Z2;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Rad4 beta-hairpin domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Anopheles albimanus (New world malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB002614-PA, ECO:0000313|Proteomes:UP000069272};
RN   [1] {ECO:0000313|EnsemblMetazoa:AALB002614-PA}
RP   IDENTIFICATION.
RC   STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB002614-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR   AlphaFoldDB; A0A182F7Z2; -.
DR   STRING; 7167.A0A182F7Z2; -.
DR   EnsemblMetazoa; AALB002614-RA; AALB002614-PA; AALB002614.
DR   VEuPathDB; VectorBase:AALB002614; -.
DR   VEuPathDB; VectorBase:AALB20_036249; -.
DR   Proteomes; UP000069272; Chromosome 2R.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR   Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR   Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR   InterPro; IPR018327; BHD_2.
DR   InterPro; IPR004583; DNA_repair_Rad4.
DR   InterPro; IPR018026; DNA_repair_Rad4-like.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR   InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR   InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR   InterPro; IPR042488; Rad4_BHD3_sf.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   NCBIfam; TIGR00605; rad4; 1.
DR   PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR   PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR   Pfam; PF10403; BHD_1; 1.
DR   Pfam; PF10404; BHD_2; 1.
DR   Pfam; PF10405; BHD_3; 1.
DR   Pfam; PF03835; Rad4; 1.
DR   SMART; SM01030; BHD_1; 1.
DR   SMART; SM01031; BHD_2; 1.
DR   SMART; SM01032; BHD_3; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          852..904
FT                   /note="Rad4 beta-hairpin"
FT                   /evidence="ECO:0000259|SMART:SM01030"
FT   DOMAIN          906..962
FT                   /note="Rad4 beta-hairpin"
FT                   /evidence="ECO:0000259|SMART:SM01031"
FT   DOMAIN          969..1043
FT                   /note="Rad4 beta-hairpin"
FT                   /evidence="ECO:0000259|SMART:SM01032"
SQ   SEQUENCE   1088 AA;  123789 MW;  8AF9F19654EF31CE CRC64;
     KISSKQHPGT FCPASFVVSS NYLHNESRYK VLKRAMDTEE KIYDEVEQED SSAADFSASE
     DEWTPEQTKE PAKKPVETKK AKGKPPATAK KPVIPAGPVR VSRRIAAKKG VELPEDTNEH
     VAAPQLELAN ESTDEETDEE EKKETKRKAK RKSSTAKRAP AKRQTQKCSI EDEPIKLTTF
     TVEQLYRKYR PDLSHPAIAP AQPSTSKAAS KAAKQPKTKD GDDLDSESSG DDYLVDPSEL
     DLSSDFFRPT KQEREQRQAV DLFFDCNAGV ELTDSEDEEA DGVPSASKRT AEPKPVKDTD
     VELGMKLLQQ VNQSTEALAQ IKRIKETQTN ASASAPAKKH AASNSTHGKM DPKLENSHRD
     DIASILHVGE KLAKHCGKSL VSGIGGRSDF VAVPSLERSA KPKDIEITLK PAVTTDAKGK
     KRTFDVLSAL KRFMNREKRN SQIHLHKLSL LCWIGHGTYV NNELRKPSLM RFAQKKLLPG
     AMSHATRPNG LTNLRYFQEL TRYFRRTVLL KDETMFYRQR RHPTVAKFLI FAIAKRAAYC
     KRDYILLFVL MLRSLGVYCR LVLSPPVPPK TVPPGQLYKM SPRTGRELAM ERQLLYDFRE
     APADSMVHMA KEKLRAQIAK QSDRKGGASE GARKRKLAVG FSIPQLDGGA DDIRRGTESG
     GSKEKKLRLM SGSFLKGESN RSKTVAPQRP LAVLAVDPLE EVRRRRARIL EAYRARAAKL
     LASKKKQAEN RKAEDSGKKI KANEKGKLGV DYWVEVFCEH EDKWITIDVL NGSVYNLEDI
     VKQATQPIAY VLAWNNDGSV KDVSPRYISR FGSIKGKLRI EDEWLERALK PYRGQRTKRD
     IIEDIKFDRL LNKRPFPEQI AEYRNHPKYA IERFLRRNEA IYPPDAPIVS RIRGEPIYLR
     SCIYTLQSRD GWLRQAKTVR MHEQPYKVVS ARAKYDRVLG TSVTGQTVEL FGEWQVEDYV
     PPVAKDGLVP RTAYGNVDLF KPCMLPKGTV HLQLPGLNRI CRRLRIDCAQ AITGFEYRSG
     GCQAVYDGFV VCEEFRERLL DEWYQEQVEL ERKEQERRRE RIHANWRRLI VGLRIRKKLK
     DRYNFDNM
//