ID A0A182F914_ANOAL Unreviewed; 667 AA.
AC A0A182F914;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Peptidase C1A papain C-terminal domain-containing protein {ECO:0000259|SMART:SM00645};
OS Anopheles albimanus (New world malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB002988-PA, ECO:0000313|Proteomes:UP000069272};
RN [1] {ECO:0000313|EnsemblMetazoa:AALB002988-PA}
RP IDENTIFICATION.
RC STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB002988-PA};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR AlphaFoldDB; A0A182F914; -.
DR STRING; 7167.A0A182F914; -.
DR EnsemblMetazoa; AALB002988-RA; AALB002988-PA; AALB002988.
DR VEuPathDB; VectorBase:AALB002988; -.
DR VEuPathDB; VectorBase:AALB20_034467; -.
DR VEuPathDB; VectorBase:AALB20_035474; -.
DR Proteomes; UP000069272; Chromosome 2R.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05356; 17beta-HSD1_like_SDR_c; 1.
DR CDD; cd02620; Peptidase_C1A_CathepsinB; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR012599; Propeptide_C1A.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43899; RH59310P; 1.
DR PANTHER; PTHR43899:SF13; RH59310P; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR Pfam; PF08127; Propeptide_C1; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT DOMAIN 415..664
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 667 AA; 72863 MW; B2E5591164E9279D CRC64;
MATVSGVLGG TSAVLVSLFI LRKVVPWIYQ NLIGPKVFGC RINVKKLGEW ALITGATDGI
GKAYAKALAK RGLNVILVSR TLSKLEDVAK EIETEFKVRT MVIDADFTGG AEIYEKIRSR
IENLEIGVLV NNVGMSYANP EYLLDLPDSE KLIQNLLNCN VLSVTRMCQL VMPGMVSRHA
GLIVNISSLS AVIPAPLLTV YAASKAYMDK LSEDLGTEYA KHNITVQSVL PGPVATNMSK
IRKSTWMACS PKVFVDSAIS TLGHARHTTG YFPHALLELA INTFSFLLPR LVERLTLNTM
QNIRARAMKK SSSNTRSAAG TQEASNVEML LHLVLLAVAV VSGSAAAGSG NKKYALSAKF
IEEINSKAST WRAGRNFHPD VSLSYIRGLM GVHQDAYKFR EPEFVHDLSA DGDDLPESFD
SREQWPNCPT IREIRDQGSC GSCWAFGAVE AMSDRVCIAS GGKIHFRFSA EDLVSCCHTC
GFGCNGGFPG AAWSYWVHKG LVSGGPFGSN QGCQPYAIAP CEHHVNGTRP SCEGEGGKTP
KCVKKCQESY TVPYAKDKRY GSKSYSIPRH EDQIRKEIMT NGPVEGAFTV YEDLLHYKEG
VYQHVTGKML GGHAIRILGW GVENNTKYWL IANSWNSDWG DNGFFKILRG EDHLGIESSI
AAGLPKL
//
