ID A0A182F9D3_ANOAL Unreviewed; 2230 AA.
AC A0A182F9D3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Protein crumbs {ECO:0008006|Google:ProtNLM};
OS Anopheles albimanus (New world malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB003108-PA, ECO:0000313|Proteomes:UP000069272};
RN [1] {ECO:0000313|EnsemblMetazoa:AALB003108-PA}
RP IDENTIFICATION.
RC STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB003108-PA};
RG EnsemblMetazoa;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 7167.A0A182F9D3; -.
DR EnsemblMetazoa; AALB003108-RA; AALB003108-PA; AALB003108.
DR VEuPathDB; VectorBase:AALB003108; -.
DR VEuPathDB; VectorBase:AALB20_037594; -.
DR Proteomes; UP000069272; Chromosome 2R.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 18.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 28.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF00008; EGF; 18.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF00054; Laminin_G_1; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00181; EGF; 29.
DR SMART; SM00179; EGF_CA; 25.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 19.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 17.
DR PROSITE; PS00022; EGF_1; 24.
DR PROSITE; PS01186; EGF_2; 18.
DR PROSITE; PS50026; EGF_3; 28.
DR PROSITE; PS01187; EGF_CA; 7.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT DOMAIN 265..301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 304..341
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 346..384
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 386..423
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 425..461
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 463..499
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 589..637
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 645..676
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 717..752
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 754..790
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 792..828
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 830..866
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 868..905
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 907..943
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 945..1010
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1012..1047
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1049..1085
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1087..1128
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1130..1305
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1307..1343
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1350..1572
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1568..1604
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1631..1840
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1841..1875
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1877..1913
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1915..1951
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1954..1995
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1996..2031
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2033..2070
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2072..2110
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2111..2152
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 291..300
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 331..340
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 355..372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 374..383
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 451..460
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 489..498
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 593..603
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 627..636
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 666..675
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 742..751
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 780..789
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 818..827
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 856..865
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 933..942
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1000..1009
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1016..1026
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1037..1046
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1075..1084
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1118..1127
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1333..1342
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1594..1603
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1865..1874
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1903..1912
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1941..1950
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1985..1994
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2021..2030
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2100..2109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2142..2151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2230 AA; 241460 MW; F3F73950AB74F1E2 CRC64;
MLGPHLHLPF AGKCLHLSVT LRRCFHFSPH SVAPALGPDK APSVIEQTNP RSPRTSNPVL
QTGGEIVFNL RVRHRHAPCT APTVTAVQTE KEAYFNGSAY LRLKTPMTLW SYSAISFKSC
RGGEILSQRY SGHALLVSVL PDWVSIVLST PSQTPLEARV TGRLLDNRWH TLELVYQLGA
LYCVIDKQPS LIANQTYNAP LIHDQEIKNE AAVLILGKQY SGCLLHGPGL VFNASAMNAE
AVVFGPCPLA AGPCSPDHDI LDPLPVDYCS HDPCMQHGTC ISRSDSYECQ CTARFKGKNC
EIDMGPPCLS YPCQHGGSCA EDSKGNYRCS CAPGYTGTVC ETELSVHPLC EKNPCANNGT
CRVGQGTGSV ECDCLKGFIG SRCETNWDDC KSNVCLNGGR CIDGVDAFTC DCKGTGYAGT
LCQNNVDECL VNPCLNGGTC FDTYGAYLCD CPPGFTGSNC QLSVNECISQ PCQNGGTCID
TREGFECRCI TGYNGQYCEL EPGCGQCPSD SECIAGRCVC KPGTTGLVGL CVEQFTVAEV
ATTSFTIPTT TFTTPSTTAA ATNSYNYTII TATSNAMAAG TSAQKSKVQS NACSNHCYNG
ASCILPTMAT GAGGGGVSFE QNFTCICASG FTGTRCESPV ALPYSDSECN CLNGGSCGPN
GSSCLCPAGY EGARCERDSS GGGNTGNGST LCNPANCAEP YRCIGGKCLC PDNMNCDNPC
ASSPCLHSGT CYAQGQDYAC KCMSGFEGKR CEEDIDECKK DGICGNGICQ NTPGSFRCFC
TPGYTGLNCD LDVDECLSHP CKNHAECQNK QNDYECICPP GYTGKDCSID IDECERNPCS
KGSTCIDQVA NFTCMCIPGM TGRLCEIDID DCESQPCQNG GRCIDQLGGF QCDCNATGYS
GIYCQTNINE CESNPCTNGA ECVDKINDYQ CNCFPGYTGK NCEEDVDECE SAPCLFGGTC
LQRSNYSLYQ PPAIAAAKGL PAHFGQPFSY SLAAGYECIC VPGTVGTNCE TNINECDSNP
CKNGVCVDGI GNYTCDCDQG FEGAHCETDI DECLKYRPCV HGTCMDGRNN YICDCDGLWG
GKNCSVQLTG CVKEPCLNGG TCVPYLENET QHKFNCSCHQ GFQGKTCDTV TTMSLVASSL
LVVNTTRDEG YDIQLRFKTT LPNGILAFGN GATSYILVLN NGRLNLHSAL LNRWDGVFIG
SELNNSKWQK VFVAINSSHL VLSANDEQTI YPINSYEGTN GSNTSFPITY LGGTTPTLAQ
PYLKHIARAV SSFVGCMEDV VINGQWVLPG QEQEFTTLHN IDTGCPRTPQ CEPNPCHSNG
HCTDLWHTFA CSCQRPHLGQ TCKYNITAAT FGHENTTNST VKVSVSDTAR RAIRSVLDIS
MFIRTRKPSG QVFYLGSDPD KQSNGLATTS NSNQSPSDDS YVAAFLSKGE LLVRMIFNDT
PEGYTVGGNK LDNGYLHLIE VIRNSTLIQV KLNGTEYFRK TLSTSGQLNA QVLYLGGPPP
HADSINSLYK DDSEKQHFKG IIQDVQVSNG SHAMIVELYP LNEEGLELPP PFGQVTIDRN
SVLEGIVSDD LCRSQPCYHD AYCENTWNDF ICTCPRGYKG KYCQDIQFCE LQKCPMNATC
QNLDAGYECI SNMTFHDDKE PLVYSFDDAA RKDISMDRIE ISYRTKFGGT LLYVHDGDMY
FEISTIRQLV TISWLLLGDL PETHRFQYDT EEDDDSYDWH TVLVQVSQNG KLEAGWKGWE
TAIDPQPSLS LDIDYFAYRH LFSGRQQIYL GGMPELAHIE NNSVVSGGTD KGSSFKGCLG
ETRVGGFLLP YFPHEVIYPD TFNFSEAHFT LNSSQPEQGC ILCFQQSCKN GGVCSDPSER
YACECPAGYE SDDCSQNIDE CLAANCTNGA TCIDGVASFT CQCVEGYEGQ LCEIEINECA
SNPCHNGGTC TDLLAGFACT CTEEYAGPQC DVFRLVTCEN APCSNGSRCI DGYNMTTGNN
FTCSCAPGFA GPLCDTPFCR LELCQNGGYC EMEAMIPYCN CLPGYVGTFC ETELNECESM
PCLNGGQCID FINEYRCNCT GTGFDGKNCE HDINECMQER ISCGGRGVCI NTEGSFRCRC
DEGMCGKDCA QFDPCQQNPD VCLNGGVCVE DCDRERRYYC NCTVGFTGFN CSEQATLEAE
ETSGADIALI VVPVVIGILT IAGALIGTFL VMARNKRATR GTYSPSAQEY CNPRLEMDNV
LKPPPEERLI
//
