ID   A0A182F9X8_ANOAL        Unreviewed;      1845 AA.
AC   A0A182F9X8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
OS   Anopheles albimanus (New world malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7167 {ECO:0000313|EnsemblMetazoa:AALB003306-PA, ECO:0000313|Proteomes:UP000069272};
RN   [1] {ECO:0000313|EnsemblMetazoa:AALB003306-PA}
RP   IDENTIFICATION.
RC   STRAIN=STECLA/ALBI9_A {ECO:0000313|EnsemblMetazoa:AALB003306-PA};
RG   EnsemblMetazoa;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the MADD family.
CC       {ECO:0000256|ARBA:ARBA00005978}.
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DR   STRING; 7167.A0A182F9X8; -.
DR   EnsemblMetazoa; AALB003306-RA; AALB003306-PA; AALB003306.
DR   VEuPathDB; VectorBase:AALB003306; -.
DR   VEuPathDB; VectorBase:AALB20_035566; -.
DR   Proteomes; UP000069272; Chromosome X.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR039980; MADD.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   3: Inferred from homology;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Membrane {ECO:0000256|ARBA:ARBA00022475}.
SQ   SEQUENCE   1845 AA;  200590 MW;  ED13732210328B48 CRC64;
     MAEQQQRDAL CPRLIDYLAI VGARATHVSR SGNGGTMGPI GAATQSSVQL PELLRRYPPM
     DHDDFPLPLD MVYFCQPEGC ISVGSRRTGP AIRDTSSFVF ALTDKDSGKT RYGICVNFYR
     LIEKTQMASA THRTGGVGGS GVAHGKQPGA ANSSLRRESW RKSMEKSSDS AFSSDYRSSN
     IAPSDSSDRD CPSRRDSDPA HGLAGPASSG AGQAGLLGVG VGPSVDSESG GSHSPSPRAS
     RKRSRSRNHS LTSLCILSHH PFQSIFRECL LILKRLIDAC NESSSPKRVG APAARVPVRG
     DSVWNVLTNQ ASEATSSVVL HDVQEIETWI LRLLSAPVPV PGSTRLELDV LSSALYQPLV
     FALPDHTRFT LVDFPLHLPL ELLGVETCLK VLTLILLEHK VIIQSRDYNA LSMSVMAFVH
     LIYPLEYMFP VIPLLPTCMG SAEQLLLAPT PYIIGLPATF LLYKRNFRLP DDIWLVDLDS
     NKLTPASGDM EAIPMLPEPE GGILKNHLKQ ALSSMSAGHA ASSASSVSLM HGRPGGSPGA
     GPGGNNRKDG VSGSSGNATG TGLPLQPPGH SSAGHTATGQ GGAGTAGATV ASLQASPVGL
     GPANPLIFGA DVDSVDVATR VAMVRFFNSQ NTLANFTEHT RILRLYPRPV VAFQINSFLR
     SRPRTSAFLN RFARTQAVEW LAEWSLTPSN VAFLRVQTGV LDPVQVGDKP KWYAHTLTPI
     RFQVWDEAST LNVALKRMLR LESQPTDDSG SDSDGADSTS SSYSSLSDFV SEIVSSDLSP
     SLHEVYATQH HHHVAPKQLS SNLDPRLVYR PPSSLRFPEG MQPPATRYGG THDERREQGR
     GGVSGGASDG VCGTGTAHDR GDDDDDDDDD DSAESSSSSR SDLSSPSFNR DSEFEFNPKT
     RNEVQLIVRP DQQQQQQQQH PQQHQQQNPQ LQQHPQQQQQ QQHRSSFENE SDSNSTTTPK
     TIVSKDSAGS LDTATDTAGS NLRPAKPAKI VPPVSPSFGR QQSGANLLAR TSSSGSTGSG
     SISHPPSLGS AGSQRQSSQG SLFEVLTSQA KELVRETTRQ SSQDGLLAQM DKLTLQAKKA
     AEEASKQALE ASKQAAGVSK NTIEDLTYVG KSTIGDLTKS AKEVAAKKGL LQQPGTAPGQ
     FPGGPSASSP TASTVATTNQ SLFSSITSDF NGIAQSTSSM FSDLFGGGNK QRHQQQQQQQ
     QQHQQHHQNQ QHQQHQQHQQ QQHVKLKEKL SFDPFPGRKG LVERNPLIKH SGPKQTKEEI
     QRIQNAERST NNSENQTFLK DLVNQVLAGE GVGWLKLNRL KKLMEDESYR MLVLGKLNRT
     LERKIGPDDH IDDVCVSKAV YKGTLKCLLA ITHGLEHTVS NFGLGGMASV FQMMEVAHTH
     FWSKELTEGV GSDMPTSLLS SQSVSPMGSR ENLRSPQSPS ELSEWTLGGA CSSRKSSTTT
     TVTMNEHGAA HHEHENQTTT EMFKDMLSMK RTMLFNKLTS FDSEGSVALQ DSSGTLSVAS
     DVLPQQQSGS DFLVASVSCR STVSDTEYEK FPKSSTLKDA KKMAGGIFSG KSSLSAGFRY
     TGGSLIPSSG SPSPDAPRVY LFEGLLGKER SGIWDQMQFW EDAFLDAVSQ ERDMIGMDQG
     PGEMMERYKA LSESERKRLE HDEDRLLSTM LYNLTAILVM LNVNKLEIKK KVRRLLGKSH
     IGFIYSQEVN LLLDQINNLH GNDIDLKPLG SRLLHRQSFT VHQGIDASGS LRFIEVRDDG
     LVLRSVNGSI TERWWFERLV NMTYSPKTKV LCLWQRNGGQ TQLHKYYTRK CKELYNCIKD
     AMERNGCAGQ AELGGEFPVQ DMNTGEGGLL QVCLEGVGLL FANSK
//